大阪大学免疫学フロンティア研究センター ヒト免疫学（単一細胞ゲノミクス）奥崎研究室

業績Publications

2024開く
  1. Oguro-Igashira E, Murakami M, Mori R, Kuwahara R, Kihara T, Kohara M, Fujiwara M, Motooka D, Okuzaki D, Arase M, Toyota H, Peng S, Ogino T, Kitabatake Y, Morii E, Hirota S, Ikeuchi H, Umemoto E, Kumanogoh A, Takeda K. The pyruvate- GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells.

    Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2318767121. doi: 10.1073/pnas.2318767121. Epub 2024 Oct 21.

  2. Liu YC, Ishikawa M, Sakakibara S, Kadi MA, Motooka D, Naito Y, Ito S, Imamura Y, Matsumoto H, Sugihara F, Hirata H, Ogura H, Okuzaki D. Full-length nanopore sequencing of circular RNA landscape in peripheral blood cells following sequential BNT162b2 mRNA vaccination.

    Gene. 2024 Sep 27:148971. doi: 10.1016/j.gene.2024.148971. Epub ahead of print.

  3. Sakakibara S, Liu YC, Ishikawa M, Edahiro R, Shirai Y, Haruna S, El Hussien MA, Xu Z, Li S, Yamaguchi Y, Murakami T, Morita T, Kato Y, Hirata H, Takeda Y, Sugihara F, Naito Y, Motooka D, Tsai CY, Ono C, Matsuura Y, Wing JB, Matsumoto H, Ogura H, Okada M, Kumanogoh A, Okada Y, Standley DM, Kikutani H, Okuzaki D. Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients.

    Life Sci Alliance. 2024 Sep 17;7(12):e202402774. doi: 10.26508/lsa.202402774.

  4. Okamoto M, Kuratani A, Okuzaki D, Kamiyama N, Kobayashi T, Sasai M, Yamamoto M. Tff1-expressing Tregs in lung prevent exacerbation of Bleomycin-induced pulmonary fibrosis.

    Front Immunol. 2024 Sep 2;15:1440918. doi: 10.3389/fimmu.2024.1440918.

  5. Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogoh A, Sakaguchi S, Ogawa Y, Arase H. Neoself-antigens are the primary target for autoreactive T cells in human lupus.

    Cell. 2024 Sep 11:S0092-8674(24)00913-9. doi: 10.1016/j.cell.2024.08.025. Epub ahead of print.

  6. Nishihara S, Koseki M, Tanaka K, Omatsu T, Saga A, Sawabe H, Inui H, Okada T, Ohama T, Okuzaki D, Kamada Y, Ono M, Nishida M, Watanabe M, Sakata Y. Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice.

    Endocr J. 2024 Sep 10. doi: 10.1507/endocrj.EJ24-0087. Epub ahead of print.

  7. Yamazaki T, Iwasaki K, Tomono S, Imai M, Miwa Y, Shizuku M, Ashimine S, Ishiyama K, Inui M, Okuzaki D, Okada M, Kobayashi T, Akashi-Takamura S. Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions.

    iScience. 2024 Aug 3;27(9):110649. doi: 10.1016/j.isci.2024.110649.

  8. Tahara S, Nojima S, Takashima T, Okuzaki D, Morii E. Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern.

    Pathol Res Pract. 2024 Aug 24;262:155562. doi: 10.1016/j.prp.2024.155562. Epub ahead of print.

  9. Yasumizu Y, Kinoshita M, Zhang MJ, Motooka D, Suzuki K, Nojima S, Koizumi N, Okuzaki D, Funaki S, Shintani Y, Ohkura N, Morii E, Okuno T, Mochizuki H. Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma.

    Cell Rep. 2024 Aug 23;43(9):114677. doi: 10.1016/j.celrep.2024.114677. Epub ahead of print.

  10. Muratsu A, Oda S, Onishi S, Yoshimura J, Matsumoto H, Togami Y, Mitsuyama Y, Ito H, Okuzaki D, Ogura H, Oda J. Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomes.

    Virol J. 2024 Aug 19;21(1):190. doi: 10.1186/s12985-024-02451-6.

  11. Yaga M, Hasegawa K, Ikeda S, Matsubara M, Hiroshima T, Kimura T, Shirai Y, Tansri W, Uehara H, Tachikawa M, Okairi Y, Sone M, Mori H, Kogue Y, Akamine H, Okuzaki D, Kawagishi K, Kawanaka S, Yamato H, Takeuchi Y, Okura E, Kanzaki R, Okami J, Nakamichi I, Nakane S, Kobayashi A, Iwazawa T, Tokunaga T, Yokouchi H, Yano Y, Uchida J, Mori M, Komuta K, Tachi T, Kuroda H, Kijima N, Kishima H, Ichii M, Futami S, Naito Y, Shiroyama T, Miyake K, Koyama S, Hirata H, Takeda Y, Funaki S, Shintani Y, Kumanogoh A, Hosen N. CD98 heavy chain protein is overexpressed in non-small cell lung cancer and is a potential target for CAR T-cell therapy.

    Sci Rep. 2024 Aug 2;14(1):17917. doi: 10.1038/s41598-024-68779-9.

  12. Nakanishi Y, Izumi M, Matsushita H, Koyama Y, Diez D, Takamatsu H, Koyama S, Nishide M, Naito M, Mizuno Y, Yamaguchi Y, Mae T, Noda Y, Nakaya K, Nojima S, Sugihara F, Okuzaki D, Ikawa M, Shimada S, Kang S, Kumanogoh A. Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.

    Neuron. 2024 Jul 9:S0896-6273(24)00452-5. doi: 10.1016/j.neuron.2024.06.017. Epub ahead of print.

  13. Nakai R, Yokota T, Tokunaga M, Takaishi M, Yokomizo T, Sudo T, Shi H, Yasumizu Y, Okuzaki D, Kokubu C, Tanaka S, Takaoka K, Yamanishi A, Yoshida J, Watanabe H, Kondoh G, Horie K, Hosen N, Sano S, Takeda J. A newly identified gene Ahed plays essential roles in murine haematopoiesis.

    Nat Commun. 2024 Jun 25;15(1):5090. doi: 10.1038/s41467-024-49252-7.

  14. Miyamoto Y, Kikuta J, Matsui T, Hasegawa T, Fujii K, Okuzaki D, Liu YC, Yoshioka T, Seno S, Motooka D, Uchida Y, Yamashita E, Kobayashi S, Eguchi H, Morii E, Tryggvason K, Shichita T, Kayama H, Atarashi K, Kunisawa J, Honda K, Takeda K, Ishii M. Periportal macrophages protect against commensal-driven liver inflammation.

    Nature. 2024 Apr 24. doi: 10.1038/s41586-024-07372-6. Epub ahead of print.

  15. Sakai H, Kamuro H, Tokunoh N, Izawa T, Tamiya S, Yamamoto A, Tanaka S, Okuzaki D, Ono C, Matsuura Y, Okada Y, Yoshioka Y, Fujio Y, Obana M. JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.

    Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00011.2024. Epub ahead of print.

  16. Zhang L, Saito H, Higashimoto T, Kaji T, Nakamura A, Iwamori K, Nagano R, Motooka D, Okuzaki D, Uezumi A, Seno S, Fukada SI. Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.

    Cell Rep. 2024 Apr 23;43(4):114052. doi: 10.1016/j.celrep.2024.114052. Epub 2024 Apr 4.

  17. Mitsuyama Y, Matsumoto H, Togami Y, Oda S, Onishi S, Yoshimura J, Murtatsu A, Ito H, Ogura H, Okuzaki D, Oda J. T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis.

    Front Immunol. 2024 Mar 20;15:1368446. doi: 10.3389/fimmu.2024.1368446.

  18. Zhang L, Saito H, Higashimoto T, Kaji T, Nakamura A, Iwamori K, Nagano R, Motooka D, Okuzaki D, Uezumi A, Seno S, Fukada SI. Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.

    Cell Rep. 2024 Apr 3;43(4):114052. doi: 10.1016/j.celrep.2024.114052. Epub ahead of print.

  19. Sasaki I, Fukuda-Ohta Y, Nakai C, Wakaki-Nishiyama N, Okamoto C, Okuzaki D, Morita S, Kaji S, Furuta Y, Hemmi H, Kato T, Yamamoto A, Tosuji E, Saitoh SI, Tanaka T, Hoshino K, Fukuda S, Miyake K, Kuroda E, Ishii KJ, Iwawaki T, Furukawa K, Kaisho T. A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages.

    Cell Rep. 2024 Mar 22;43(4):113981. doi: 10.1016/j.celrep.2024.113981. Epub ahead of print.

  20. Varner LR, Chaya T, Maeda Y, Tsutsumi R, Zhou S, Tsujii T, Okuzaki D, Furukawa T. The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases.

    iScience. 2024 Mar 1;27(4):109380. doi: 10.1016/j.isci.2024.109380.

  21. Fujimoto R, Oda S, Matsumoto H, Nakao S, Shimizu K, Okuzaki D, Oda J. Longitudinal whole blood transcriptome analysis of a septic shock patient with secondary hemophagocytic syndrome.

    QJM. 2024 Mar 9:hcae043. doi: 10.1093/qjmed/hcae043. Epub ahead of print.

  22. Yasumizu Y, Takeuchi D, Morimoto R, Takeshima Y, Okuno T, Kinoshita M, Morita T, Kato Y, Wang M, Motooka D, Okuzaki D, Nakamura Y, Mikami N, Arai M, Zhang X, kumanogoh A, Mochizuki H, Ohkura N, Sakaguchi S. Single-cell transcriptomelandscape of circulating CD4+ T cell populations in autoimmune diseases.

    Cell Genom. 2024 Feb 14;4(2):100473. doi: 10.1016/j.xgen.2023.100473.Epub 2024 Jan 3.

  23. Li J, Hua Y, Liu Y, Qu X, Zhang J, Ishida M, Yoshida N, Tabata A, Miyoshi H, Shiba M, Higo S, Sougawa N, Takeda M, Kawamura T, Matsuura R, Okuzaki D, Toyofuku T, Sawa Y, Liu L, Miyagawa S. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment.

    iScience. 2024 Jan 23;27(2):108992. doi: 10.1016/j.isci.2024.108992.

  24. Toshida K, Itoh S, Iseda N, Tomiyama T, Yoshiya S, Toshima T, Liu YC, Iwasaki T, Okuzaki D, Taniguchi K, Oda Y, Mori M, Yoshizumi T. Impact of ACSL4 on the prognosis of hepatocellular carcinoma: Association with cancer-associatedfibroblasts and the tumour immune microenvironment.

    Liver Int. 2024 Jan 31. doi:10.1111/liv.15839. Epub ahead of print.

  25. Satoh S, Miyake K, Adachi Y, Masuhiro K, Futami S, Naito Y, Shiroyama T,Koyama S, Yamaguchi Y, Konaka H, Takamatsu H, Okuzaki D, Nagatomo I, Takeda Y,Kumanogoh A. Cancer-associated SNRPD3 mutation confers resistance to hypoxia,which is attenuated by DRP1 inhibition.

    Biochem Biophys Res Commun. 2024 Feb12;696:149511. doi: 10.1016/j.bbrc.2024.149511. Epub 2024 Jan 10.

  26. Amano K, Okuzaki D, Kitaoka Y, Kato S, Fujiwara M, Tanaka S, Iida S. Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation.

    J Dent Res. 2024 Jan 17:220345231221954. doi: 10.1177/00220345231221954. Epub ahead of print.

  27. Suzuki A, Nojima S, Tahara S, Motooka D, Kohara M, Okuzaki D, Hirokawa M,Morii E. Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors.

    J Pathol Transl Med. 2024 Jan;58(1):22-28. doi: 10.4132/jptm.2023.11.21. Epub 2024 Jan 10.

  28. Endo T, Kobayashi K, Matsumura T, Emori C, Ozawa M, Kawamoto S, Okuzaki D,Shimada K, Miyata H, Shimada K, Kodani M, Ishikawa-Yamauchi Y, Motooka D, Hara E, Ikawa M. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice.

    Commun Biol. 2024 Jan 4;7(1):16. doi:10.1038/s42003-023-05685-2.

  29. Kang S, Onishi S, Ling Z, Inoue H, Zhang Y, Chang H, Zhao H, Wang T, Okuzaki D, Matsuura H, Takamatsu H, Oda J, Kishimoto T. Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.

    Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2315898120. doi: 10.1073/pnas.2315898120. Epub 2024 Jan 2.

2023開く
  1. Liu L, Ito T, Li B, Tani H, Okuzaki D, Motooka D, Miyazaki H, Ogino T,Nakamura S, Takeda K, Kayama H. The UDP-glucose/P2Y14 receptor axis promoteseosinophil-dependent large intestinal inflammation.

    Int Immunol. 2023 Dec 18:dxad050. doi: 10.1093/intimm/dxad050. Epub ahead of print.

  2. Sakai S, Tanaka Y, Tsukamoto Y, Kimura-Ohba S, Hesaka A, Hamase K, Hsieh CL,Kawakami E, Ono H, Yokote K, Yoshino M, Okuzaki D, Matsumura H, Fukushima A,Mita M, Nakane M, Doi M, Isaka Y, Kimura T. d-Alanine Affects the Circadian Clock to Regulate Glucose Metabolism in Kidney.

    Kidney360. 2023 Dec 15. doi: 10.34067/KID.0000000000000345. Epub ahead of print.

  3. Shibata K, Fujimori N, Oono T, Motooka D, Okuzaki D, Sonoda KH, Ogawa Y,Yamasaki S. Single-cell analysis for identification of T-cell clonotypes associated with IgG4 production of autoimmune pancreatitis.

    Gastroenterol Rep (Oxf). 2023 Dec 8;11:goad071. doi: 10.1093/gastro/goad071.

  4. Yoshimura J, Togami Y, Ebihara T, Matsumoto H, Mitsuyama Y, Sugihara F,Hirata H, Okuzaki D, Ogura H. Classification of patients with COVID-19 by blood RNA endotype: a prospective cohort study.

    Microbiol Spectr. 2023 Dec 12;11(6):e0264523. doi: 10.1128/spectrum.02645-23. Epub 2023 Nov 15.

  5. Tsuneki H, Sugiyama M, Sato K, Ito H, Nagai S, Kon K, Wada T, Kobayashi N,Okada T, Toyooka N, Kawasaki M, Ito T, Otsubo R, Okuzaki D, Yasui T, Sasaoka T. Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice.

    Eur J Pharmacol. 2023 Dec 15;961:176190. doi: 10.1016/j.ejphar.2023.176190. Epub 2023 Nov 11.

  6. Kurosu T, Okuzaki D, Sakai Y, Kadi MA, Phanthanawiboon S, Ami Y, Shimojima M,Yoshikawa T, Fukushi S, Nagata N, Suzuki T, Kamimura D, Murakami M, Ebihara H,Saijo M. Dengue virus infection induces selective expansion of Vγ4 and Vγ6TCR γδ T cells in the small intestine and a cytokine storm driving vascular leakage in mice.

    PLoS Negl Trop Dis. 2023 Nov 8;17(11):e0011743. doi: 10.1371/journal.pntd.0011743.

  7. Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T. Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

    Cell Stem Cell. 2023 Oct 5;30(10):1315-1330.e10. doi: 10.1016/j.stem.2023.09.001.

  8. Tsai CY, Sakakibara S, Kuan YD, Omori H, El Hussien MA, Okuzaki D, Lu SL, Noda T, Tabata K, Nakamura S, Yoshimori T, Kikutani H. Opposing roles of RUBCN isoforms in autophagy and memory B cell generation.

    Sci Signal. 2023 Sep 19;16(803):eade3599. doi: 10.1126/scisignal.ade3599. Epub 2023 Sep 19.

  9. Nakatani A, Okumura R, Ishibashi A, Okamoto S, Sakaki K, Ito Y, Okuzaki D,Inohara H, Takeda K. Differential dependence on microbiota of IL-23/IL-22-dependent gene expression between the small- and large-intestinal epithelia.

    Genes Cells. 2023 Nov;28(11):776-788. doi: 10.1111/gtc.13065. Epub 2023 Sep 7.

  10. Amano K, Kitaoka Y, Kato S, Fujiwara M, Okuzaki D, Aikawa T, Kogo M, Iida S. Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base Synchondrosis.

    J Dent Res. 2023 Oct;102(11):1241-1251. doi: 10.1177/00220345231184405. Epub 2023 Aug 14.

  11. Kanki H, Matsumoto H, Togami Y, Okuzaki D, Ogura H, Sasaki T, Mochizuki H.Importance of microRNAs by mRNA-microRNA integration analysis in acute ischemic stroke patients.

    J Stroke Cerebrovasc Dis. 2023 Sep;32(9):107277. doi: 10.1016/j.jstrokecerebrovasdis.2023.107277. Epub 2023 Aug 8.

  12. Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, Yari S, Sato T, Kamakura T, Oshima K, Imai R, Liu YC, Okuzaki D, Hara T, Motooka D, Emoto N, Inohara H, Ishii M. Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction.

    Nat Commun. 2023 Aug 3;14(1):4417. doi: 10.1038/s41467-023-40094-3.

  13. Murayama N, Miyaki T, Okuzaki D, Shibata Y, Koji T, Inoue A, Aoki J, Hayashi H, Tanaka Y, Murota H. Transcriptome Profiling of Anhidrotic Eccrine Sweat Glands Reveals that Olfactory Receptors on Eccrine Sweat Glands Regulate Perspiration in a Ligand-Dependent Manner.

    JID Innov. 2023 Mar 15;3(4):100196. doi: 10.1016/j.xjidi.2023.100196.

  14. Onishi S, Matsumoto H, Sugihara F, Ebihara T, Matsuura H, Osuka A, Okuzaki D, Ogura H, Oda J. Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome.

    iScience. 2023 Jul 3;26(8):107271. doi: 10.1016/j.isci.2023.107271.

  15. Kishimoto H, Iwasaki M, Wada K, Horitani K, Tsukamoto O, Kamikubo K, Nomura S, Matsumoto S, Harada T, Motooka D, Okuzaki D, Takashima S, Komuro I, Kikuchi A, Shiojima I. Wnt5a-YAP signaling axis mediates mechanotransduction in cardiacmyocytes and contributes to contractile dysfunction induced by pressure overload.

    iScience. 2023 Jun 15;26(7):107146. doi: 10.1016/j.isci.2023.107146.

  16. Okamoto M, Sasai M, Kuratani A, Okuzaki D, Arai M, Wing JB, Sakaguchi S,Yamamoto M. A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.

    Cell Rep. 2023 Jul 25;42(7):112813. doi: 10.1016/j.celrep.2023.112813. Epub 2023 Jul 12.

  17. Noshita S, Kubo Y, Kajiwara K, Okuzaki D, Nada S, Okada M. A TGF-β-responsive enhancer regulates SRC expression and epithelial-mesenchymal transition-associated cell migration.

    J Cell Sci. 2023 Aug 1;136(15):jcs261001. doi: 10.1242/jcs.261001. Epub 2023 Aug 9.

  18. Taniguchi M, Okumura R, Matsuzaki T, Nakatani A, Sakaki K, Okamoto S,Ishibashi A, Tani H, Horikiri M, Kobayashi N, Yoshikawa HY, Motooka D, Okuzaki D, Nakamura S, Kida T, Kameyama A, Takeda K. Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon.

    Mucosal Immunol. 2023 Oct;16(5):624-641. doi: 10.1016/j.mucimm.2023.06.004. Epub 2023 Jul 13.

  19. Mitsuhara C, Togami Y, Hirose T, Nakao S, Ito H, Matsumoto H, Ogura H,Okuzaki D, Oda J. Whole-blood ribonucleic acid sequencing analysis in methemoglobinemia: a case report.

    J Med Case Rep. 2023 Jun 10;17(1):238. doi: 10.1186/s13256-023-03976-0.

  20. Yokoi K, Yasumizu Y, Ohkura N, Shinzawa K, Okuzaki D, Shimoda N, Ando H,Yamada N, Fujimoto M, Tanemura A. Increased anti-oxidative action compensates for collagen tissue degeneration in vitiligo dermis.

    Pigment Cell Melanoma Res. 2023 Sep;36(5):355-364. doi: 10.1111/pcmr.13094. Epub 2023 May 25.

  21. Naito Y, Koyama S, Masuhiro K, Hirai T, Uenami T, Inoue T, Osa A, Machiyama H, Watanabe G, Sax N, Villa J, Kinugasa-Katayama Y, Nojima S, Yaga M, Hosono Y,Okuzaki D, Satoh S, Tsuda T, Nakanishi Y, Suga Y, Morita T, Fukushima K, ishide M, Shiroyama T, Miyake K, Iwahori K, Hirata H, Nagatomo I, Yano Y, Tamiya M,Kumagai T, Takemoto N, Inohara H, Yamasaki S, Yamashita K, Aoshi T, Akbay EA,Hosen N, Shintani Y, Takamatsu H, Mori M, Takeda Y, Kumanogoh A. Tumor-derived semaphorin 4A improves PD-1-locking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation.

    Sci Adv. 2023 May 19;9(20):eade0718. doi: 10.1126/sciadv.ade0718. Epub 2023 May 19.

  22. Ichihara M, Takahashi H, Nishida N, Ivan C, Okuzaki D, Yokoyama Y, Ohtsuka M, Miyoshi N, Uemura M, Tanaka S, Calin GA, Mori M, Doki Y, Eguchi H, Yamamoto H. Long noncoding RNA 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer.

    Ann Gastroenterol Surg. 2022 Dec 29;7(3):458-470. doi: 10.1002/ags3.12649.

  23. Morita R, Kubota-Koketsu R, Lu X, Sasaki T, Nakayama EE, Liu YC, Okuzaki D,Motooka D, Wing JB, Fujikawa Y, Ichida Y, Amo K, Goto T, Hara J, Shirano M, Yamasaki S, Shioda T. COVID-19 relapse associated with SARS-CoV-2 evasion from CD4+ T-cell recognition in an agammaglobulinemia patient.

    iScience. 2023 May 19;26(5):106685. doi: 10.1016/j.isci.2023.106685. Epub 2023 Apr 20.

  24. Edahiro R, Shirai Y, Takeshima Y, Sakakibara S, Yamaguchi Y, Murakami T, Morita T, Kato Y, Liu YC, Motooka D, Naito Y, Takuwa A, Sugihara F, Tanaka K, Wing JB, Sonehara K, Tomofuji Y; Japan COVID-19 Task Force; Namkoong H, Tanaka H, Lee H, Fukunaga K, Hirata H, Takeda Y, Okuzaki D, Kumanogoh A, Okada Y. Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.

    Nat Genet. 2023 May;55(5):753-767. doi: 10.1038/s41588-023-01375-1. Epub 2023 Apr 24.

  25. Itakura H, Hata T, Okuzaki D, Takeda K, Iso K, Qian Y, Morimoto Y, Adachi T, Hirose H, Yokoyama Y, Ogino T, Miyoshi N, Takahashi H, Uemura M, Mizushima T, Hinoi T, Mori M, Doki Y, Eguchi H, Yamamoto H. Tumor-suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer.

    iScience. 2023 Mar 23;26(4):106478. doi: 10.1016/j.isci.2023.106478.

  26. Tsukamoto Y, Nakamura Y, Hirata M, Okuzaki D, Sakate R, Kimura T. GCN2 kinase-mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln (CUG) charging under amino acid starvation.

    FEBS Lett. 2023 Jun;597(12):1638-1650. doi: 10.1002/1873-3468.14628. Epub 2023 May 2.

  27. Harada M, Okuzaki D, Yamauchi A, Ishikawa S, Nomura Y, Nishimura A, Motoike Y, Koshikawa M, Hitachi K, Tsuchida K, Amano K, Maekawa A, Takagi Y, Watanabe E, Ozaki Y, Izawa H. Circulating miR-20b-5p and miR-330-3p are novel biomarkers for progression of atrial fibrillation: Intracardiac/extracardiac plasma sample analysis by small RNA sequencing.

    PLoS One. 2023 Apr 4;18(4):e0283942. doi: 10.1371/journal.pone.0283942.

  28. Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K. Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.

    Sci Immunol. 2023 Mar 31;8(81):eadc9324. doi: 10.1126/sciimmunol.adc9324. Epub 2023 Mar 31.

  29. Qu X, Li J, Liu L, Zhang J, Hua Y, Suzuki K, Harada A, Ishida M, Yoshida N, Okuzaki D, Sakai Y, Sawa Y, Miyagawa S. ONO-1301 enhances post-transplantation survival of human induced pluripotent stem cell-derived cardiac tissue sheet by promoting angiogenesis.

    J Heart Lung Transplant. 2023 Jun;42(6):716-729. doi: 10.1016/j.healun.2023.01.018. Epub 2023 Feb 10.

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    Front Immunol. 2023 Feb 23;14:998233. doi: 10.3389/fimmu.2023.998233.

  31. Yari S, Kikuta J, Shigyo H, Miyamoto Y, Okuzaki D, Furusawa Y, Minoshima M, Kikuchi K, Ishii M. JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors.

    Inflamm Regen. 2023 Mar 3;43(1):18. doi: 10.1186/s41232-023-00268-4.

  32. Kitakaze M, Uemura M, Hara T, Chijimatsu R, Motooka D, Hirai T, Konno M, Okuzaki D, Sekido Y, Hata T, Ogino T, Takahashi H, Miyoshi N, Ofusa K, Mizushima T, Eguchi H, Doki Y, Ishii H. Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.

    Br J Cancer. 2023 May;128(10):1828-1837. doi: 10.1038/s41416-023-02202-4. Epub 2023 Mar 3.

  33. Chaya T, Maeda Y, Sugimura R, Okuzaki D, Watanabe S, Varner LR, Motooka D, Gyoten D, Yamamoto H, Kato H, Furukawa T. Correction: Multiple knockout mouse and embryonic stem cell models reveal the role of miR-124a in neuronal maturation.

    J Biol Chem. 2023 Mar;299(3):103066. doi: 10.1016/j.jbc.2023.103066. Epub 2023 Mar 1. Erratum for: J Biol Chem. 2022 Sep;298(9):102293.

  34. Al Kadi M, Okuzaki D. Unfolding the Bacterial Transcriptome Landscape Using Oxford Nanopore Technology Direct RNA Sequencing.

    Methods Mol Biol. 2023;2632:269-279. doi: 10.1007/978-1-0716-2996-3_19.

  35. Tomiyama T, Itoh S, Iseda N, Toshida K, Kosai-Fujimoto Y, Tomino T, Kurihara T, Nagao Y, Morita K, Harada N, Liu YC, Okuzaki D, Kohashi K, Oda Y, Mori M, Yoshizumi T. ASO Visual Abstract: Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.

    Ann Surg Oncol. 2023 Jun;30(6):3390-3391. doi: 10.1245/s10434-023-13182-3.

  36. Kido K, Nojima S, Motooka D, Nomura Y, Kohara M, Sato K, Ohshima K, Tahara S, Kurashige M, Umeda D, Takashima T, Kiyokawa H, Ukon K, Matsui T, Okuzaki D, Morii E. Ovarian high-grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance.

    J Pathol. 2023 May;260(1):56-70. doi: 10.1002/path.6064. Epub 2023 Mar 17.

  37. Inui H, Nishida M, Ichii M, Nakaoka H, Asaji M, Ide S, Saito S, Saga A, Omatsu T, Tanaka K, Kanno K, Chang J, Zhu Y, Okada T, Okuzaki D, Matsui T, Ohama T, Koseki M, Morii E, Hosen N, Yamashita S, Sakata Y. XCR1+ conventional dendritic cell-induced CD4+ T helper 1 cell activation exacerbates cardiac remodeling after ischemic myocardial injury.

    J Mol Cell Cardiol. 2023 Mar;176:68-83. doi: 10.1016/j.yjmcc.2023.01.011. Epub 2023 Feb 3.

  38. Hashizaki E, Sasai M, Okuzaki D, Nishi T, Kobayashi T, Iwanaga S, Yamamoto M. Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

    mBio. 2023 Feb 28;14(1):e0325622. doi: 10.1128/mbio.03256-22. Epub 2023 Jan 30.

  39. Søndergaard JN, Tulyeu J, Edahiro R, Shirai Y, Yamaguchi Y, Murakami T, Morita T, Kato Y, Hirata H, Takeda Y, Okuzaki D, Sakaguchi S, Kumanogoh A, Okada Y, Wing JB. A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.

    Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2217902120. doi: 10.1073/pnas.2217902120. Epub 2023 Jan 20.

  40. Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu YC, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M. In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma.

    Nat Commun. 2023 Jan 17;14(1):143. doi: 10.1038/s41467-022-35701-8.

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    Oncol Lett. 2022 Dec 14;25(2):45. doi: 10.3892/ol.2022.13631.

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    Biochem Biophys Rep. 2022 Dec 28;33:101416. doi: 10.1016/j.bbrep.2022.101416.

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    Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2204269120. doi: 10.1073/pnas.2204269120. Epub 2022 Dec 27.

  44. Arai Y, Yamanaka I, Okamoto T, Isobe A, Nakai N, Kamimura N, Suzuki T, Daidoji T, Ono T, Nakaya T, Matsumoto K, Okuzaki D, Watanabe Y. Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists.

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    Hepatol Res. 2023 Apr;53(4):370-376. doi: 10.1111/hepr.13866. Epub 2022 Dec 13.

  46. Ebihara T, Matsubara T, Togami Y, Matsumoto H, Tachino J, Matsuura H, Kojima T, Sugihara F, Seno S, Okuzaki D, Hirata H, Ogura H. Combination of WFDC2, CHI3L1, and KRT19 in Plasma Defines a Clinically Useful Molecular Phenotype Associated with Prognosis in Critically Ill COVID-19 Patients.

    J Clin Immunol. 2023 Feb;43(2):286-298. doi: 10.1007/s10875-022-01386-3. Epub 2022 Nov 4.

  47. Suzuki R, Ono Y, Noshita K, Kim KS, Ito H, Morioka Y, Tamura T, Okuzaki D, Tagawa T, Takenaka T, Yoshizumi T, Shimamura T, Iwami S, Fukuhara T. Smoking enhances the expression of angiotensin-converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection.

    Microbiol Immunol. 2023 Jan;67(1):22-31. doi: 10.1111/1348-0421.13034. Epub 2022 Nov 2.

  48. Nakatani A, Tsuda T, Maeda Y, Hayama M, Okuzaki D, Obata S, Kishikawa T, Takeda K, Inohara H. S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis.

    Allergol Int. 2023 Jan;72(1):143-150. doi: 10.1016/j.alit.2022.08.005. Epub 2022 Sep 16.

2022開く
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    Ann Gastroenterol Surg. 2022 Dec 29;7(3):458-470. doi: 10.1002/ags3.12649.

  2. Kusumoto S, Ikeda JI, Kurashige M, Maeno-Fujinami E, Tahara S, Matsui T, Nojima S, Okuzaki D, Morii E. Tumor cell plasticity in endometrioid carcinoma is regulated by neuronal membrane glycoprotein M6-b.

    Oncol Lett. 2022 Dec 14;25(2):45. doi: 10.3892/ol.2022.13631.

  3. Zhou H, Xie Z, Morikawa N, Sakurai F, Mizuguchi H, Okuzaki D, Okada N, Tachibana M. Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism.

    Biochem Biophys Rep. 2022 Dec 28;33:101416. doi: 10.1016/j.bbrep.2022.101416.

  4. Yokoi T, Murakami M, Kihara T, Seno S, Arase M, Wing JB, Søndergaard JN, Kuwahara R, Minagawa T, Oguro-Igashira E, Motooka D, Okuzaki D, Mori R, Ikeda A, Sekido Y, Amano T, Iijima H, Ozono K, Mizushima T, Hirota S, Ikeuchi H, Takeda K. Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn's disease.

    Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2204269120. doi: 10.1073/pnas.2204269120.

  5. Saga A, Koseki M, Kanno K, Chang J, Higo T, Okuzaki D, Okada T, Inui H, Asaji M, Tanaka K, Omatsu T, Nishihara S, Zhu Y, Ito K, Hattori H, Ichi I, Kamada Y, Ono M, Saibara T, Ohama T, Hikoso S, Nishida M, Yamashita S, Sakata Y. A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice.

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  6. Arai Y, Yamanaka I, Okamoto T, Isobe A, Nakai N, Kamimura N, Suzuki T, Daidoji T, Ono T, Nakaya T, Matsumoto K, Okuzaki D, Watanabe Y. Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists.

    iScience. 2023 Jan 20;26(1):105742. doi: 10.1016/j.isci.2022.105742. Epub 2022 Dec 7.

  7. Kawai H, Osawa Y, Tsunoda T, Matsuda M, Okawara M, Sakamoto Y, Shimagaki T, Tsutsui Y, Yoshida Y, Yoshikawa S, Doi H, Mori T, Yamazoe T, Yoshio S, Okamura T, Sugiyama M, Okuzaki D, Komatsu H, Inui A, Yanaga K, Ikegami T, Kanto T. Peripheral-dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy.

    Hepatol Res. 2023 Apr;53(4):370-376. doi: 10.1111/hepr.13866. Epub 2022 Dec 13.

  8. Ito H, Ishikawa M, Matsumoto H, Sugihara F, Okuzaki D, Hirata H, Ogura H. Transcriptional differences between coronavirus disease 2019 and bacterial sepsis.

    Virol J. 2022 Nov 28;19(1):198. doi: 10.1186/s12985-022-01930-y.

  9. Tsuneki H, Sugiyama M, Ito T, Sato K, Matsuda H, Onishi K, Yubune K, Matsuoka Y, Nagai S, Yamagishi T, Maeda T, Honda K, Okekawa A, Watanabe S, Yaku K, Okuzaki D, Otsubo R, Nomoto M, Inokuchi K, Nakagawa T, Wada T, Yasui T, Sasaoka T. Food odor perception promotes systemic lipid utilization.

    Nat Metab. 2022 Nov;4(11):1514-1531. doi: 10.1038/s42255-022-00673-y. Epub 2022 Nov 14.

  10. Shibata K, Motozono C, Nagae M, Shimizu T, Ishikawa E, Motooka D, Okuzaki D, Izumi Y, Takahashi M, Fujimori N, Wing JB, Hayano T, Asai Y, Bamba T, Ogawa Y, Furutani-Seiki M, Shirai M, Yamasaki S. Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.

    Nat Commun. 2022 Nov 14;13(1):6948. doi: 10.1038/s41467-022-34802-8.

  11. Ebihara T, Matsubara T, Togami Y, Matsumoto H, Tachino J, Matsuura H, Kojima T, Sugihara F, Seno S, Okuzaki D, Hirata H, Ogura H. Combination of WFDC2, CHI3L1, and KRT19 in Plasma Defines a Clinically Useful Molecular Phenotype Associated with Prognosis in Critically Ill COVID-19 Patients.

    J Clin Immunol. 2023 Feb;43(2):286-298. doi: 10.1007/s10875-022-01386-3. Epub 2022 Nov 4.

  12. Yamaguchi Y, Kato Y, Edahiro R, Søndergaard JN, Murakami T, Amiya S, Nameki S, Yoshimine Y, Morita T, Takeshima Y, Sakakibara S, Naito Y, Motooka D, Liu YC, Shirai Y, Okita Y, Fujimoto J, Hirata H, Takeda Y, Wing JB, Okuzaki D, Okada Y, Kumanogoh A. Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells.

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    Microbiol Immunol. 2023 Jan;67(1):22-31. doi: 10.1111/1348-0421.13034. Epub 2022 Nov 2.

  15. Tomimatsu M, Matsumoto K, Ashizuka M, Kumagai S, Tanaka S, Nakae T, Yokota K, Kominami S, Kajiura R, Okuzaki D, Motooka D, Shiraishi A, Abe T, Matsuda H, Okada Y, Maeda M, Seno S, Obana M, Fujio Y. Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling.

    Sci Rep. 2022 Oct 5;12(1):16656. doi: 10.1038/s41598-022-21202-7.

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    Allergol Int. 2023 Jan;72(1):143-150. doi: 10.1016/j.alit.2022.08.005. Epub 2022 Sep 16.

  17. Naito M, Nakanishi Y, Motomura Y, Takamatsu H, Koyama S, Nishide M, Naito Y, Izumi M, Mizuno Y, Yamaguchi Y, Nojima S, Okuzaki D, Kumanogoh A. Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung.

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  24. Togami Y, Matsumoto H, Yoshimura J, Matsubara T, Ebihara T, Matsuura H, Mitsuyama Y, Kojima T, Ishikawa M, Sugihara F, Hirata H, Okuzaki D, Ogura H. Significance of interferon signaling based on mRNA-microRNA integration and plasma protein analyses in critically ill COVID-19 patients.

    Mol Ther Nucleic Acids. 2022 Sep 13;29:343-353. doi: 10.1016/j.omtn.2022.07.005. Epub 2022 Jul 13.

  25. Chijimatsu R, Kobayashi S, Takeda Y, Kitakaze M, Tatekawa S, Arao Y, Nakayama M, Tachibana N, Saito T, Ennishi D, Tomida S, Sasaki K, Yamada D, Tomimaru Y, Takahashi H, Okuzaki D, Motooka D, Ohshiro T, Taniguchi M, Suzuki Y, Ogawa K, Mori M, Doki Y, Eguchi H, Ishii H. Establishment of a reference single- cell RNA sequencing dataset for human pancreatic adenocarcinoma.

    iScience. 2022 Jun 22;25(8):104659. doi: 10.1016/j.isci.2022.104659.

  26. Takemura M, Yamaguchi M, Kobayashi M, Sumitomo T, Hirose Y, Okuzaki D, Ono M, Motooka D, Goto K, Nakata M, Uzawa N, Kawabata S. Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model.

    Front Cell Infect Microbiol. 2022 Jul 1;12:844000. doi: 10.3389/fcimb.2022.844000.

  27. Ebihara T, Matsumoto H, Matsubara T, Togami Y, Nakao S, Matsuura H, Onishi S, Kojima T, Sugihara F, Okuzaki D, Hirata H, Yamamura H, Ogura H. Resistin Associated With Cytokines and Endothelial Cell Adhesion Molecules Is Related to Worse Outcome in COVID-19.

    Front Immunol. 2022 Jun 16;13:830061. doi: 10.3389/fimmu.2022.830061.

  28. Ouji Y, Misu M, Kitamura T, Okuzaki D, Yoshikawa M. Impaired differentiation potential of CD34-positive cells derived from mouse hair follicles after long- term culture.

    Sci Rep. 2022 Jun 30;12(1):11011. doi: 10.1038/s41598-022-15354-9.

  29. Sano E, Suzuki T, Hashimoto R, Itoh Y, Sakamoto A, Sakai Y, Saito A, Okuzaki D, Motooka D, Muramoto Y, Noda T, Takasaki T, Sakuragi JI, Minami S, Kobayashi T, Yamamoto T, Matsumura Y, Nagao M, Okamoto T, Takayama K. Cell response analysis in SARS-CoV-2 infected bronchial organoids.

    Commun Biol. 2022 May 30;5(1):516. doi: 10.1038/s42003-022-03499-2.

  30. Otake-Kasamoto Y, Kayama H, Kishikawa T, Shinzaki S, Tashiro T, Amano T, Tani M, Yoshihara T, Li B, Tani H, Liu L, Hayashi A, Okuzaki D, Motooka D, Nakamura S, Okada Y, Iijima H, Takeda K, Takehara T. Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response.

    J Exp Med. 2022 Jul 4;219(7):e20211291. doi: 10.1084/jem.20211291. Epub 2022 May 24.

  31. Xie Z, Kawasaki T, Zhou H, Okuzaki D, Okada N, Tachibana M. Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF.

    Front Pharmacol. 2022 Apr 25;13:873792. doi: 10.3389/fphar.2022.873792.

  32. Al Kadi M, Jung N, Okuzaki D. UNAGI: Yeast Transcriptome Reconstruction and Gene Discovery Using Nanopore Sequencing.

    Methods Mol Biol. 2022;2477:79-89. doi: 10.1007/978-1-0716-2257-5_6.

  33. Masuhiro K, Tamiya M, Fujimoto K, Koyama S, Naito Y, Osa A, Hirai T, Suzuki H, Okamoto N, Shiroyama T, Nishino K, Adachi Y, Nii T, Kinugasa-Katayama Y, Kajihara A, Morita T, Imoto S, Uematsu S, Irie T, Okuzaki D, Aoshi T, Takeda Y, Kumagai T, Hirashima T, Kumanogoh A. Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.

    JCI Insight. 2022 May 9;7(9):e157915. doi: 10.1172/jci.insight.157915.

  34. El Hussien MA, Tsai CY, Satouh Y, Motooka D, Okuzaki D, Ikawa M, Kikutani H, Sakakibara S. Corrigendum to: Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient- derived anti-dsDNA antibody in knock-in mice.

    Int Immunol. 2022 Mar 25;34(4):225. doi: 10.1093/intimm/dxac007. Erratum for: Int Immunol. 2022 Mar 25;34(4):207-223.

  35. Uenaka M, Yamashita E, Kikuta J, Morimoto A, Ao T, Mizuno H, Furuya M, Hasegawa T, Tsukazaki H, Sudo T, Nishikawa K, Okuzaki D, Motooka D, Kosaka N, Sugihara F, Boettger T, Braun T, Ochiya T, Ishii M. Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo.

    Nat Commun. 2022 Feb 24;13(1):1066. doi: 10.1038/s41467-022-28673-2.

  36. Kanno K, Koseki M, Chang J, Saga A, Inui H, Okada T, Tanaka K, Asaji M, Zhu Y, Ide S, Saito S, Higo T, Okuzaki D, Ohama T, Nishida M, Kamada Y, Ono M, Saibara T, Yamashita S, Sakata Y. Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis- related cardiomyopathy.

    Sci Rep. 2022 Feb 22;12(1):2996. doi: 10.1038/s41598-022-06542-8.

  37. Kimura T, Hayama Y, Okuzaki D, Nada S, Okada M. The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB.

    J Biol Chem. 2022 Mar;298(3):101744. doi: 10.1016/j.jbc.2022.101744. Epub 2022 Feb 18.

  38. Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S. CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.

    Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2114282119. doi: 10.1073/pnas.2114282119.

  39. Ebihara T, Matsumoto H, Matsubara T, Togami Y, Nakao S, Matsuura H, Kojima T, Sugihara F, Okuzaki D, Hirata H, Yamamura H, Ogura H. Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis.

    Front Immunol. 2022 Jan 12;12:798338. doi: 10.3389/fimmu.2021.798338.

  40. Pareek S, Sanchenkova X, Sakaguchi T, Murakami M, Okumura R, Kayama H, Kawauchi S, Motooka D, Nakamura S, Okuzaki D, Kishimoto T, Takeda K. Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine.

    Genes Cells. 2022 Apr;27(4):243-253. doi: 10.1111/gtc.12922. Epub 2022 Feb 6.

  41. El Hussien MA, Tsai CY, Satouh Y, Motooka D, Okuzaki D, Ikawa M, Kikutani H, Sakakibara S. Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice.

    Int Immunol. 2022 Mar 25;34(4):207-223. doi: 10.1093/intimm/dxab111. Erratum in: Int Immunol. 2022 Mar 25;34(4):225.

  42. Kawai H, Osawa Y, Matsuda M, Tsunoda T, Yanagida K, Hishikawa D, Okawara M, Sakamoto Y, Shimagaki T, Tsutsui Y, Yoshida Y, Yoshikawa S, Hashi K, Doi H, Mori T, Yamazoe T, Yoshio S, Sugiyama M, Okuzaki D, Komatsu H, Inui A, Tamura-Nakano M, Oyama C, Shindou H, Kusano H, Kage M, Ikegami T, Yanaga K, Kanto T. Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy.

    Hepatology. 2022 Jul;76(1):112-125. doi: 10.1002/hep.32256. Epub 2021 Dec 22.

  43. Takeda T, Yokoyama Y, Takahashi H, Okuzaki D, Asai K, Itakura H, Miyoshi N, Kobayashi S, Uemura M, Fujita T, Ueno H, Mori M, Doki Y, Fujii H, Eguchi H, Yamamoto H. A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells.

    Br J Cancer. 2022 Jan;126(1):109-119. doi: 10.1038/s41416-021-01579-4. Epub 2021 Oct 27.

  44. Chaya T, Ishikane H, Varner LR, Sugita Y, Maeda Y, Tsutsumi R, Motooka D, Okuzaki D, Furukawa T. Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity.

    Hum Mol Genet. 2022 Feb 21;31(4):535-547. doi: 10.1093/hmg/ddab268.

2021開く
  1. Kawai H, Osawa Y, Matsuda M, Tsunoda T, Yanagida K, Hishikawa D, Okawara M, Sakamoto Y, Shimagaki T, Tsutsui Y, Yoshida Y, Yoshikawa S, Hashi K, Doi H, Mori T, Yamazoe T, Yoshio S, Sugiyama M, Okuzaki D, Komatsu H, Inui A, Tamura-Nakano M, Oyama C, Shindou H, Kusano H, Kage M, Ikegami T, Yanaga K, Kanto T. Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy.

    Hepatology. 2021 Dec 2. doi: 10.1002/hep.32256. Online ahead of print.

  2. Tsuji Y, Nonoguchi N, Okuzaki D, Wada Y, Motooka D, Hirota Y, Toho T, Yoshikawa N, Furuse M, Kawabata S, Miyatake SI, Nakamura H, Yamamoto R, Nakamura S, Kuroiwa T, Wanibuchi M. Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression.

    Sci Rep. 2021 Nov 11;11(1):22110. doi: 10.1038/s41598-021-01475-0.

  3. Al Kadi, M.; Ishii, E.; Truong, D. T.; Motooka, D.; Matsuda, S.; Iida, T.; Kodama, T.; Okuzaki, D. Direct RNA Sequencing Unfolds the Complex Transcriptome of Vibrio Parahaemolyticus.

    mSystems 2021, e0099621.

  4. Shinomiya, H.; Kato, H.; Kuramoto, Y.; Watanabe, N.; Tsuruda, T.; Arimura, T.; Miyashita, Y.; Miyasaka, Y.; Mashimo, T.; Takuwa, A.; Motooka, D.; Okuzaki, D.; Matsuoka, K.; Tsukamoto, O.; Hakui, H.; Yamada, N.; Lee, J.-K.; Kioka, H.; Kitakaze, M.; Takashima, S.; Sakata, Y.; Asano, Y. Aberrant Accumulation of TMEM43 Accompanied by Perturbed Transmural Gene Expression in Arrhythmogenic Cardiomyopathy.

    FASEB J . 2021 35 (11), e21994.

  5. Hesaka A, Tsukamoto Y, Nada S, Kawamura M, Ichimaru N, Sakai S, Nakane M, Mita M, Okuzaki D, Okada M, Isaka Y, Kimura T. d-Serine Mediates Cellular Proliferation for Kidney Remodeling. Kidney360. 2021 Aug 16;2(10):1611-1624. doi: 10.34067/KID.0000832021. eCollection 2021 Oct 28.
  6. Takashi Takeda, Yuhki Yokoyama, Hidekazu Takahashi, Daisuke Okuzaki, Kaho Asai, Hiroaki Itakura, Norikatsu Miyoshi, Shogo Kobayashi, Mamoru Uemura, Toshitsugu Fujita, Hiroo Ueno, Masaki Mori, Yuichiro Doki, Hodaka Fujii, Hidetoshi Eguchi, Hirofumi Yamamoto. A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells.

    British journal of cancer 2021 Oct.

  7. Ohshima, K.; Oi, R.; Okuzaki, D.; Motooka, D.; Shinohara, M.; Nojima, S.; Morii, E. Mitochondrial Matrix Protein C14orf159 Attenuates Colorectal Cancer Metastasis by Suppressing Wnt/β-Catenin Signalling.

    Br J Cancer. 2021 Dec;125(12):1699-1711. doi: 10.1038/s41416-021-01582-9. Epub 2021 Oct 23.

  8. Nishikawa, K.; Seno, S.; Yoshihara, T.; Narazaki, A.; Sugiura, Y.; Shimizu, R.; Kikuta, J.; Sakaguchi, R.; Suzuki, N.; Takeda, N.; Semba, H.; Yamamoto, M.; Okuzaki, D.; Motooka, D.; Kobayashi, Y.; Suematsu, M.; Koseki, H.; Matsuda, H.; Yamamoto, M.; Tobita, S.; Mori, Y.; Ishii, M. Osteoclasts Adapt to Physioxia Perturbation through DNA Demethylation.

    EMBO Rep . 2021, e53035. https://doi.org/10.15252/embr.202153035.

  9. Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki. Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma.

    Bio Rxiv. 2021 Dec.

  10. Tahara S, Nojima S, Ohshima K, Hori Y, Sato K, Kurashige M, Matsui T, Okuzaki D, Morii E. Nicotinamide N-methyltransferase is related to MELF pattern invasion in endometrioid carcinoma.

    Cancer Med. 2021 Dec;10(23):8630-8640. doi: 10.1002/cam4.4359. Epub 2021 Oct 16.

  11. Tani, H.; Li, B.; Kusu, T.; Okumura, R.; Nishimura, J.; Okuzaki, D.; Motooka, D.; Arakawa, S.; Mori, A.; Yoshihara, T.; Ogino, T.; Tsai, S.-H.; Furuta, Y.; Muneta, M.; Nakamura, S.; Fukusaki, E.; Yamamoto, K.; Yagita, H.; Kayama, H.; Takeda, K. The ATP-Hydrolyzing Ectoenzyme E-NTPD8 Attenuates Colitis through Modulation of P2X4 Receptor-Dependent Metabolism in Myeloid Cells.

    Proc Natl Acad Sci U S A . 2021 118 (39), e2100594118. https://doi.org/10.1073/pnas.2100594118.

  12. Horitani, K.; Iwasaki, M.; Kishimoto, H.; Wada, K.; Nakano, M.; Park, H.; Adachi, Y.; Motooka, D.; Okuzaki, D.; Shiojima, I. Repetitive Spikes of Glucose and Lipid Induce Senescence-like Phenotypes of Bone Marrow Stem Cells through H3K27me3 Demethylase-Mediated Epigenetic Regulation.

    Am J Physiol Heart Circ Physiol . 2021.

  13. Chaya, T.; Ishikane, H.; Varner, L. R.; Sugita, Y.; Maeda, Y.; Tsutsumi, R.; Motooka, D.; Okuzaki, D.; Furukawa, T. Deficiency of the Neurodevelopmental Disorder-Associated Gene Cyfip2 Alters the Retinal Ganglion Cell Properties and Visual Acuity.

    Hum Mol Genet . 2021 ddab268. https://doi.org/10.1093/hmg/ddab268.

  14. Ishikura, T.; Kinoshita, M.; Shimizu, M.; Yasumizu, Y.; Motooka, D.; Okuzaki, D.; Yamashita, K.; Murata, H.; Beppu, S.; Koda, T.; Tada, S.; Shiraishi, N.; Sugiyama, Y.; Miyamoto, K.; Kusunoki, S.; Sugimoto, T.; Kumanogoh, A.; Okuno, T.; Mochizuki, H. Anti-AQP4 Autoantibodies Promote ATP Release from Astrocytes and Induce Mechanical Pain in Rats.

    J Neuroinflammation. 2021 18 (1), 181.

  15. Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC, Okuzaki D, Gemechu Y, Kang S, Kishimoto T. The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.

    Cancer Lett. 2021 Nov 1;520:295-306. doi: 10.1016/j.canlet.2021.08.004. Epub 2021 Aug 10.

  16. Sudo, T.; Motomura, Y.; Okuzaki, D.; Hasegawa, T.; Yokota, T.; Kikuta, J.; Ao, T.; Mizuno, H.; Matsui, T.; Motooka, D.; Yoshizawa, R.; Nagasawa, T.; Kanakura, Y.; Moro, K.; Ishii, M. Group 2 Innate Lymphoid Cells Support Hematopoietic Recovery under Stress Conditions.

    J Exp Med . 2021 218 (5).

  17. Suga Y, Nagatomo I, Kinehara Y, Koyama S, Okuzaki D, Osa A, Naito Y, Takamatsu H, Nishide M, Nojima S, Ito D, Tsuda T, Nakatani T, Nakanishi Y, Futami Y, Koba T, Satoh S, Hosono Y, Miyake K, Fukushima K, Shiroyama T, Iwahori K, Hirata H, Takeda Y, Kumanogoh A. IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity.

    J Immunol. 2021 Sep 1;207(5):1456-1467. doi: 10.4049/jimmunol.2100076. Epub 2021 Aug 11.

  18. Funato Y, Yamazaki D, Okuzaki D, Yamamoto N, Miki H. Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.

    Nat Commun. 2021 Jun 17;12(1):3683. doi: 10.1038/s41467-021-24063-2.

  19. Adachi T, Zhao W, Minami K, Yokoyama Y, Okuzaki D, Kondo R, Takahashi Y, Tamari K, Seo Y, Isohashi F, Yamamoto H, Koizumi M, Ogawa K. Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.

    J Radiat Res. 2021 Sep 13;62(5):764-772. doi: 10.1093/jrr/rrab049.

  20. Parajuli G, Tekguc M, Wing JB, Hashimoto A, Okuzaki D, Hirata T, Sasaki A, Itokazu T, Handa H, Sugino H, Nishikawa Y, Metwally H, Kodama Y, Tanaka S, Sabe H, Yamashita T, Sakaguchi S, Kishimoto T, Hashimoto S. Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.

    Cancer Immunol Res. 2021 Aug;9(8):862-876. doi: 10.1158/2326-6066.CIR-21-0014. Epub 2021 May 18.

  21. Nakamura T, Takagi S, Okuzaki D, Matsui S, Fujisato T. Hypoxia transactivates cholecystokinin gene expression in 3D-engineered muscle.

    J Biosci Bioeng. 2021 Jul;132(1):64-70. doi: 10.1016/j.jbiosc.2021.03.006. Epub 2021 Apr 8.

  22. Morimoto A, Kikuta J, Nishikawa K, Sudo T, Uenaka M, Furuya M, Hasegawa T, Hashimoto K, Tsukazaki H, Seno S, Nakamura A, Okuzaki D, Sugihara F, Ninomiya A, Yoshimura T, Takao-Kawabata R, Matsuda H, Ishii M. SLPI is a critical mediator that controls PTH-induced bone formation.

    Nat Commun. 2021 Apr 9;12(1):2136. doi: 10.1038/s41467-021-22402-x.

  23. Hirose, Y.; Yamaguchi, M.; Sumitomo, T.; Nakata, M.; Hanada, T.; Okuzaki, D.; Motooka, D.; Mori, Y.; Kawasaki, H.; Coady, A.; Uchiyama, S.; Hiraoka, M.; Zurich, R. H.; Amagai, M.; Nizet, V.; Kawabata, S. Streptococcus Pyogenes Upregulates Arginine Catabolism to Exert Its Pathogenesis on the Skin Surface.

    Cell Rep 2021, 34 (13), 108924.

  24. 横山雄起, 武田和, 藤田敏次, 奥崎大介, 杉山真美, 浅井香穂, 高橋秀和, 藤井穂高, 森正樹, 山本浩文, 山本浩文. 大腸癌における三次元ゲノム構造を介したKLF5遺伝子発現制御メカニズム, 日本癌学会学術総会抄録集(Web) 79th 338-338 2020年
  25. Chang J, Koseki M, Saga A, Kanno K, Higo T, Okuzaki D, Okada T, Inui H, Tanaka K, Asaji M, Zhu Y, Kamada Y, Ono M, Saibara T, Ichi I, Ohama T, Nishida M, Yamashita S, Sakata Y. Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice.

    Front Endocrinol (Lausanne). 2021 Mar 10;11:614692. doi: 10.3389/fendo.2020.614692. eCollection 2020.

  26. Chee WY, Kurahashi Y, Kim J, Miura K, Okuzaki D, Ishitani T, Kajiwara K, Nada S, Okano H, Okada M. β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells.

    Commun Biol. 2021 Mar 19;4(1):357. doi: 10.1038/s42003-021-01879-8.

  27. Matsuura H, Matsumoto H, Okuzaki D, Shimizu K, Ogura H, Ebihara T, Matsubara T, Hirano SI, Shimazu T. Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.

    J Surg Res. 2021 Jul;263:63-70. doi: 10.1016/j.jss.2021.01.022.

  28. Kajiwara K, Yamano S, Aoki K, Okuzaki D, Matsumoto K, Okada M. CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.

    Life Sci Alliance. 2021 Feb 11;4(4):e202000832. doi: 10.26508/lsa.202000832. Print 2021 Apr.

  29. Yamaguchi, M.; Win, H. P. M.; Higashi, K.; Ono, M.; Hirose, Y.; Motooka, D.; Okuzaki, D.; Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.

    Microb Genom. 2021 Feb;7(2):000523. doi: 10.1099/mgen.0.000523.

  30. Shingai Y, Yokota T, Okuzaki D, Sudo T, Ishibashi T, Doi Y, Ueda T, Ozawa T, Nakai R, Tanimura A, Ichii M, Shibayama H, Kanakura Y, Hosen N. Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.

    Stem Cells. 2021 Jun;39(6):723-736. doi: 10.1002/stem.3348. Epub 2021 Feb 15.

2020開く
  1. Kohama, Y.; Higo, S.; Masumura, Y.; Shiba, M.; Kondo, T.; Ishizu, T.; Higo, T.; Nakamura, S.; Kameda, S.; Tabata, T.; Inoue, H.; Motooka, D.; Okuzaki, D.; Takashima, S.; Miyagawa, S.; Sawa, Y.; Hikoso, S.; Sakata, Y. Adeno-Associated Virus-Mediated Gene Delivery Promotes S-Phase Entry-Independent Precise Targeted Integration in Cardiomyocytes.

    Scientific Reports. 2020 Sep 18; 10 (1), 15348.

  2. Iwamoto, K.; Takahashi, H.; Okuzaki, D.; Osawa, H.; Ogino, T.; Miyoshi, N.; Uemura, M.; Matsuda, C.; Yamamoto, H.; Mizushima, T.; Mori, M.; Doki, Y.; Eguchi, H. Syntenin-1 Promotes Colorectal Cancer Stem Cell Expansion and Chemoresistance by Regulating Prostaglandin E2 Receptor.

    British Journal of Cancer. 2020 Sep; 123 (6), 955–964.

  3. Makino, S., Takahashi, H., Okuzaki, D., Miyoshi, N., Haraguchi, N., Hata, T., Matsuda, C., Yamamoto, H., Mizushima, T., Mori, M., Doki, Y. Erratum: DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer (Carcinogenesis (bgz157) DOI: 10.1093/carcin/bgz157).

    Carcinogenesis 2020 41(3) 394-396.

  4. Tone, M.; Tahara, S.; Nojima, S.; Motooka, D.; Okuzaki, D.; Morii, E. HTR3A Is Correlated with Unfavorable Histology and Promotes Proliferation through ERK Phosphorylation in Lung Adenocarcinoma.

    Cancer Sci. 2020 Oct;111(10):3953-3961. doi: 10.1111/cas.14592.

  5. Sakaguchi, T.; Okumura, R.; Ono, C.; Okuzaki, D.; Kawai, T.; Okochi, Y.; Tanimura, N.; Murakami, M.; Kayama, H.; Umemoto, E.; Kioka, H.; Ohtani, T.; Sakata, Y.; Miyake, K.; Okamura, Y.; Baba, Y.; Takeda, K. TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.

    Cell Reports. 2020 Jun 9; 31 (10), 107755. https://doi.org/10.1016/j.celrep.2020.107755

  6. Sato, A.; Ono, C.; Tamura, T.; Mori, H.; Izumi, T.; Torii, S.; Fauzyah, Y.; Yamamoto, T.; Morioka, Y.; Okuzaki, D.; Fukuhara, T.; Matsuura, Y. Rimonabant Suppresses RNA Transcription of Hepatitis B Virus by Inhibiting Hepatocyte Nuclear Factor 4α.

    Microbiol. Immunol. 2020, 64 (5), 345–355.

  7. Nagasawa, M.; Tomimatsu, K.; Terada, K.; Kondo, K.; Miyazaki, K.; Miyazaki, M.; Motooka, D.; Okuzaki, D.; Yoshida, T.; Kageyama, S.; Kawamoto, H.; Kawauchi, A.; Agata, Y. Long Non-Coding RNA MANCR Is a Target of BET Bromodomain Protein BRD4 and Plays a Critical Role in Cellular Migration and Invasion Abilities of Prostate Cancer.

    Biochem Biophys Res Commun. 2020 May 21; 526 (1), 128–134.

  8. Makino, S.; Takahashi, H.; Okuzaki, D.; Miyoshi, N.; Haraguchi, N.; Hata, T.; Matsuda, C.; Yamamoto, H.; Mizushima, T.; Mori, M.; Doki, Y. DCLK1 Integrates Induction of TRIB3, EMT, Drug Resistance and Poor Prognosis in Colorectal Cancer.

    Carcinogenesis 2020, 41 (3), 394–396.

  9. Kawasaki, K.; Nojima, S.; Hijiki, S.; Tahara, S.; Ohshima, K.; Matsui, T.; Hori, Y.; Kurashige, M.; Umeda, D.; Kiyokawa, H.; Kido, K.; Okuzaki, D.; Morii, E. FAM111B Enhances Proliferation of KRAS-Driven Lung Adenocarcinoma by Degrading P16.

    Cancer Sci. 2020 Jul;111(7):2635-2646 .

  10. Iwatani, S.; Shinzaki, S.; Amano, T.; Otake, Y.; Tani, M.; Yoshihara, T.; Tsujii, Y.; Hayashi, Y.; Inoue, T.; Okuzaki, D.; Mizushima, T.; Miyoshi, E.; Iijima, H.; Takehara, T. Oligosaccharide-Dependent Anti-Inflammatory Role of Galectin-1 for Macrophages in Ulcerative Colitis.

    J Gastroenterol. Hepatol. 2020 Dec;35(12):2158-2169.

  11. Amano, K.; Okuzaki, D.; Aikawa, T.; Kogo, M. Indian Hedgehog in Craniofacial Neural Crest Cells Links to Skeletal Malocclusion by Regulating Associated Cartilage Formation and Gene Expression.

    FASEB J. 2020 May; 34 (5), 6791–6807.

  12. Yoshimura, Y.; Okuzaki, D. Error-Free and Error-Prone DNA Repair Gene Expression Data through Reprogramming and Passage in Human IPS Cells.

    Data Brief. 2020 Feb 6; 29, 105228.

  13. Tsuda, T.; Nishide, M.; Maeda, Y.; Hayama, Y.; Koyama, S.; Nojima, S.; Takamatsu, H.; Okuzaki, D.; Morita, T.; Nakatani, T.; Kato, Y.; Nakanishi, Y.; Futami, Y.; Suga, Y.; Naito, Y.; Konaka, H.; Satoh, S.; Naito, M.; Izumi, M.; Obata, S.; Nakatani, A.; Shikina, T.; Takeda, K.; Hayama, M.; Inohara, H.; Kumanogoh, A. Pathological and Therapeutic Implications of Eosinophil-Derived Semaphorin 4D in Eosinophilic Chronic Rhinosinusitis.

    J Allergy Clin. Immunol. 2020 Mar; 145 (3), 843-854.e4.

  14. Nagate, Y.; Ezoe, S.; Fujita, J.; Okuzaki, D.; Motooka, D.; Ishibashi, T.; Ichii, M.; Tanimura, A.; Kurashige, M.; Morii, E.; Fukushima, T.; Suehiro, Y.; Yokota, T.; Shibayama, H.; Oritani, K.; Kanakura, Y. Ectonucleotidase CD39 Is Highly Expressed on ATLL Cells and Is Responsible for Their Immunosuppressive Function.

    Leukemia 2020.

  15. Morimoto, Y.; Mizushima, T.; Wu, X.; Okuzaki, D.; Yokoyama, Y.; Inoue, A.; Hata, T.; Hirose, H.; Qian, Y.; Wang, J.; Miyoshi, N.; Takahashi, H.; Haraguchi, N.; Matsuda, C.; Doki, Y.; Mori, M.; Yamamoto, H. miR-4711-5p Regulates Cancer Stemness and Cell Cycle Progression via KLF5, MDM2 and TFDP1 in Colon Cancer Cells.

    Br. J. Cancer 2020, 122 (7), 1037–1049.

  16. Ikeda, A.; Ogino, T.; Kayama, H.; Okuzaki, D.; Nishimura, J.; Fujino, S.; Miyoshi, N.; Takahashi, H.; Uemura, M.; Matsuda, C.; Yamamoto, H.; Takeda, K.; Mizushima, T.; Mori, M.; Doki, Y. Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer.

    Cancer Immunol Res. 2020.

  17. Hashimoto, K.; Kaito, T.; Furuya, M.; Seno, S.; Okuzaki, D.; Kikuta, J.; Tsukazaki, H.; Matsuda, H.; Yoshikawa, H.; Ishii, M. In Vivo Dynamic Analysis of BMP-2-Induced Ectopic Bone Formation.

    Sci Rep. 2020 Mar 16; 10 (1), 4751.

  18. Okuzaki, D.; Yamauchi, T.; Mitani, F.; Miyata, M.; Ninomiya, Y.; Watanabe, R.; Akamatsu, H.; Oneyama, C. C-Src Promotes Tumor Progression through Downregulation of MicroRNA-129-1-3p.

    Cancer Sci. 2020, 111 (2), 418–428.

  19. Suzuki T, Itoh Y, Sakai Y, Saito A, Okuzaki D, Motooka D, Minami S, Kobayashi T, Yamamoto T, Okamoto T, Takayama K. Generation of human bronchial organoids for SARS-CoV-2 research.

    Bio Rxiv. 2020 May.

  20. Makino S, Takahashi H, Okuzaki D, Miyoshi N, Haraguchi N, Hata T, Matsuda C, Yamamoto H, Mizushima T, Mori M, Doki Y. DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer (vol 41, pg 303, 2020).

    CARCINOGENESIS 2020 Mar 41(3) 394-396.

  21. 柴田 雅朗, 谷口 高平, 奥崎 大介, 近藤 洋一. 総説 エクソソームmicroRNAと乳癌. 乳癌基礎研究 28 63-69 2020年8月
  22. Yamanishi, K.; Hashimoto, T.; Miyauchi, M.; Mukai, K.; Ikubo, K.; Uwa, N.; Watanabe, Y.; Ikawa, T.; Okuzaki, D.; Okamura, H.; Yamanishi, H.; Matsunaga, H. Analysis of Genes Linked to Depressive-like Behaviors in Interleukin-18-Deficient Mice: Gene Expression Profiles in the Brain.

    Biomed Rep 2020 Jan; 12 (1), 3–10.

  23. Ohshima, K.; Nojima, S.; Tahara, S.; Kurashige, M.; Kawasaki, K.; Hori, Y.; Taniguchi, M.; Umakoshi, Y.; Okuzaki, D.; Wada, N.; Ikeda, J.-I.; Fukusaki, E.; Morii, E. Serine Racemase Enhances Growth of Colorectal Cancer by Producing Pyruvate from Serine.

    Nature Metabolism. 2020 Jan; 2 (1), 81–96.

  24. Ichii, M.; Oritani, K.; Toda, J.; Saito, H.; Shi, H.; Shibayama, H.; Motooka, D.; Kitai, Y.; Muromoto, R.; Kashiwakura, J.-I.; Saitoh, K.; Okuzaki, D.; Matsuda, T.; Kanakura, Y. Signal-Transducing Adaptor Protein-2 Delays Recovery of B Lineage Lymphocytes during Hematopoietic Stress.

    Haematologica. 2020 Feb 1;106(2):424-436.

  25. Al Kadi, M.; Jung, N.; Ito, S.; Kameoka, S.; Hishida, T.; Motooka, D.; Nakamura, S.; Iida, T.; Okuzaki, D. UNAGI: An Automated Pipeline for Nanopore Full-Length CDNA Sequencing Uncovers Novel Transcripts and Isoforms in Yeast.

    Funct Integr Genomics 2020 Jul;20(4):523-536.

  26. Morimatsu, M.; Yamashita, E.; Seno, S.; Sudo, T.; Kikuta, J.; Mizuno, H.; Okuzaki, D.; Motooka, D.; Ishii, M. Migration Arrest of Chemoresistant Leukemia Cells Mediated by MRTF-SRF Pathway.

    Inflamm Regen. 2020 Jul 6 ; 40, 15.

  27. Izumi, T.; Sakata, K.; Okuzaki, D.; Inokuchi, S.; Tamura, T.; Motooka, D.; Nakamura, S.; Ono, C.; Shimokawa, M.; Matsuura, Y.; Mori, M.; Fukuhara, T.; Yoshizumi, T. Characterization of Human Pegivirus Infection in Liver Transplantation Recipients.

    J Med. Virol. 2019 Dec; 91 (12), 2093–2100.

  28. Qian, Y.; Wu, X.; Yokoyama, Y.; Okuzaki, D.; Taguchi, M.; Hirose, H.; Wang, J.; Hata, T.; Inoue, A.; Hiraki, M.; Ohtsuka, M.; Takahashi, H.; Haraguchi, N.; Mizushima, T.; Tanaka, S.; Mori, M.; Yamamoto, H. E-Cadherin-Fc Chimera Protein Matrix Enhances Cancer Stem-like Properties and Induces Mesenchymal Features in Colon Cancer Cells.

    Cancer Sci. 2019 , Nov; 110 (11), 3520–3532.

  29. Osada-Oka, M.; Goda, N.; Saiga, H.; Yamamoto, M.; Takeda, K.; Ozeki, Y.; Yamaguchi, T.; Soga, T.; Tateishi, Y.; Miura, K.; Okuzaki, D.; Kobayashi, K.; Matsumoto, S. Metabolic Adaptation to Glycolysis Is a Basic Defense Mechanism of Macrophages for Mycobacterium Tuberculosis Infection.

    Int. Immunol. 2019 Nov 8 ; 31 (12), 781–793.

  30. Okuzaki D, Yamauchi T, Mitani F, Miyata M, Ninomiya Y, Watanabe R, Akamatsu H, Oneyama C. c-Src promotes tumor progression through downregulation of microRNA-129-1-3p.

    Cancer Sci. 2020 Feb;111(2):418-428. doi: 10.1111/cas.14269. Epub 2020 Jan 17.

  31. 田原紳一郎, 野島聡, 大島健司, 堀由美子, 倉重真沙子, 和田直樹, 本山雄一, 奥崎大介, 池田純一郎, 森井英一. SDPRは子宮体部類内膜癌においてILKを介してALDH1を制御する.

    日本癌学会学術総会抄録集(Web) 79th 2020年

2019開く
  1. Okuzaki D, Yamauchi T, Mitani F, Miyata M, Ninomiya Y, Watanabe R, Akamatsu H, Oneyama C. c-Src promotes tumor progression via donwregulation of miR-129-1-3p. Cancer Science 2019 Dec.
  2. Kajiwara K, Aoki K, Okuzaki D, Matsumoto K, Okada M . CDCP1 controls compensatory renal growth by integrating Src and Met signaling. bioRxiv 2019 Oct.
  3. Kamitani, T.; Murota, H.; Arase, N.; Wataya-Kaneda, M.; Sato-Nishiuchi, R.; Sekiguchi, K.; Okuzaki, D.; Motooka, D.; Katayama, I. Expression of Polydom in Dermal Neurofibroma and Surrounding Dermis in von Recklinghausen’s Disease.

    J Dermatol Sci. 2019 Nov; 96 (2), 73–80.

  4. Hirose, Y.; Yamaguchi, M.; Okuzaki, D.; Motooka, D.; Hamamoto, H.; Hanada, T.; Sumitomo, T.; Nakata, M.; Kawabata, S. Streptococcus Pyogenes Transcriptome Changes in the Inflammatory Environment of Necrotizing Fasciitis.

    Appl. Environ. Microbiol. 2019, 85 (21).

  5. Imai, R.; Sato, T.; Iwamoto, Y.; Hanada, Y.; Terao, M.; Ohta, Y.; Osaki, Y.; Imai, T.; Morihana, T.; Okazaki, S.; Oshima, K.; Okuzaki, D.; Katayama, I.; Inohara, H. Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling.

    J Assoc Res Otolaryngol. 2019 Oct; 20 (5), 449–459.

  6. Okamoto, M.; Ali, M.; Komichi, S.; Watanabe, M.; Huang, H.; Ito, Y.; Miura, J.; Hirose, Y.; Mizuhira, M.; Takahashi, Y.; Okuzaki, D.; Kawabata, S.; Imazato, S.; Hayashi, M. Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement.

    J Clin Med 2019 Sep 11 ; 8 (9).

  7. Itoh, K.; Ebata, T.; Hirata, H.; Torii, T.; Sugimoto, W.; Onodera, K.; Nakajima, W.; Uehara, I.; Okuzaki, D.; Yamauchi, S.; Budirahardja, Y.; Nishikata, T.; Tanaka, N.; Kawauchi, K. DMPK Is a New Candidate Mediator of Tumor Suppressor P53-Dependent Cell Death.

    Molecules. Sep 1; 2019, 24 (17).

  8. Ikawa, T.; Watanabe, Y.; Okuzaki, D.; Goto, N.; Okamura, N.; Yamanishi, K.; Higashino, T.; Yamanishi, H.; Okamura, H.; Higashino, H. A New Approach to Identifying Hypertension-Associated Genes in the Mesenteric Artery of Spontaneously Hypertensive Rats and Stroke-Prone Spontaneously Hypertensive Rats.

    J Hypertens. 2019 Aug; 37 (8), 1644–1656.

  9. Bando, H.; Pradipta, A.; Iwanaga, S.; Okamoto, T.; Okuzaki, D.; Tanaka, S.; Vega-Rodríguez, J.; Lee, Y.; Ma, J. S.; Sakaguchi, N.; Soga, A.; Fukumoto, S.; Sasai, M.; Matsuura, Y.; Yuda, M.; Jacobs-Lorena, M.; Yamamoto, M. CXCR4 Regulates Plasmodium Development in Mouse and Human Hepatocytes.

    J Exp Med. 2019 Aug 5; 216 (8), 1733–1748.

  10. Tahara, S.; Nojima, S.; Ohshima, K.; Hori, Y.; Kurashige, M.; Wada, N.; Motoyama, Y.; Okuzaki, D.; Ikeda, J.-I.; Morii, E. Serum Deprivation-Response Protein Regulates Aldehyde Dehydrogenase 1 through Integrin-Linked Kinase Signaling in Endometrioid Carcinoma Cells.

    Cancer Sci. 2019 May; 110 (5), 1804–1813.

  11. Ueda, T.; Yokota, T.; Okuzaki, D.; Uno, Y.; Mashimo, T.; Kubota, Y.; Sudo, T.; Ishibashi, T.; Shingai, Y.; Doi, Y.; Ozawa, T.; Nakai, R.; Tanimura, A.; Ichii, M.; Ezoe, S.; Shibayama, H.; Oritani, K.; Kanakura, Y. Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.

    Stem Cell Reports 2019, 13 (6), 992–1005.

  12. Hasegawa, T.; Kikuta, J.; Sudo, T.; Matsuura, Y.; Matsui, T.; Simmons, S.; Ebina, K.; Hirao, M.; Okuzaki, D.; Yoshida, Y.; Hirao, A.; Kalinichenko, V. V.; Yamaoka, K.; Takeuchi, T.; Ishii, M. Identification of a Novel Arthritis-Associated Osteoclast Precursor Macrophage Regulated by FoxM1.

    Nat Immunol. 2019, 20 (12), 1631–1643.

  13. Konno, M.; Koseki, J.; Asai, A.; Yamagata, A.; Shimamura, T.; Motooka, D.; Okuzaki, D.; Kawamoto, K.; Mizushima, T.; Eguchi, H.; Takiguchi, S.; Satoh, T.; Mimori, K.; Ochiya, T.; Doki, Y.; Ofusa, K.; Mori, M.; Ishii, H. Distinct Methylation Levels of Mature MicroRNAs in Gastrointestinal Cancers.

    Nat Commun. 2019 Aug 29; 10 (1), 3888.

  14. 森本祥悠, 高橋秀和, 呉しん, 奥崎大介, 横山雄起, 荻野崇之, 三吉範克, 植村守, 松田宙, 永島恒和, 森正樹, 土岐祐一郎, 山本浩文, 山本浩文. KLF5とTFDP1をターゲットとした大腸癌に対する新規核酸治療としてのmiR-4711-5p.

    日本癌学会学術総会抄録集(Web) 78th E-1101 2019年

  15. Tsuda, T.; Maeda, Y.; Nishide, M.; Koyama, S.; Hayama, Y.; Nojima, S.; Takamatsu, H.; Okuzaki, D.; Kinehara, Y.; Kato, Y.; Nakatani, T.; Obata, S.; Akazawa, H.; Shikina, T.; Takeda, K.; Hayama, M.; Inohara, H.; Kumanogoh, A. Eosinophil-Derived Neurotoxin Enhances Airway Remodeling in Eosinophilic Chronic Rhinosinusitis and Correlates with Disease Severity.

    Int Immunol. 2019 Feb 6; 31 (1), 33–40.

  16. Nawa, N.; Hirata, K.; Kawatani, K.; Nambara, T.; Omori, S.; Banno, K.; Kokubu, C.; Takeda, J.; Nishimura, K.; Ohtaka, M.; Nakanishi, M.; Okuzaki, D.; Taniguchi, H.; Arahori, H.; Wada, K.; Kitabatake, Y.; Ozono, K. Elimination of Protein Aggregates Prevents Premature Senescence in Human Trisomy 21 Fibroblasts.

    PLoS ONE 2019, 14 (7), e0219592.

  17. Nakata, J.; Nakajima, H.; Hayashibara, H.; Imafuku, K.; Morimoto, S.; Fujiki, F.; Motooka, D.; Okuzaki, D.; Hasegawa, K.; Hosen, N.; Tsuboi, A.; Oka, Y.; Kumanogoh, A.; Oji, Y.; Sugiyama, H. Extremely Strong Infiltration of WT1-Specific CTLs into Mouse Tumor by the Combination Vaccine with WT1-Specific CTL and Helper Peptides.

    Oncotarget 2018, 9 (89), 36029–36038.

2018開く
  1. Fukata, T.; Mizushima, T.; Nishimura, J.; Okuzaki, D.; Wu, X.; Hirose, H.; Yokoyama, Y.; Kubota, Y.; Nagata, K.; Tsujimura, N.; Inoue, A.; Miyoshi, N.; Haraguchi, N.; Takahashi, H.; Hata, T.; Matsuda, C.; Kayama, H.; Takeda, K.; Doki, Y.; Mori, M.; Yamamoto, H. The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis.

    Mol Ther Nucleic Acids 2018 Sep 7; 12, 658–671.

  2. Kokuda, R.; Watanabe, R.; Okuzaki, D.; Akamatsu, H.; Oneyama, C. MicroRNA-137-Mediated Src Oncogenic Signaling Promotes Cancer Progression.

    Genes Cells 2018.

  3. Toratani, M.; Konno, M.; Asai, A.; Koseki, J.; Kawamoto, K.; Tamari, K.; Li, Z.; Sakai, D.; Kudo, T.; Satoh, T.; Sato, K.; Motooka, D.; Okuzaki, D.; Doki, Y.; Mori, M.; Ogawa, K.; Ishii, H. A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones.

    Cancer Res. 2018, 78 (23), 6703–6707.

  4. Yamanishi, K.; Maeda, S.; Kuwahara-Otani, S.; Hashimoto, T.; Ikubo, K.; Mukai, K.; Nakasho, K.; Gamachi, N.; El-Darawish, Y.; Li, W.; Okuzaki, D.; Watanabe, Y.; Yamanishi, H.; Okamura, H.; Matsunaga, H. Deficiency in Interleukin-18 Promotes Differentiation of Brown Adipose Tissue Resulting in Fat Accumulation despite Dyslipidemia.

    J Transl Med 2018, 16 (1), 314.

  5. Tsai, C.-Y.; Sakakibara, S.; Yasui, T.; Minamitani, T.; Okuzaki, D.; Kikutani, H. Bystander Inhibition of Humoral Immune Responses by Epstein-Barr Virus LMP1.

    Int Immunol. 2018 Nov 14; 30 (12), 579–590.

  6. Inoue A, Mizushima T, Wu X, Okuzaki D, Kambara N, Ishikawa S, Wang J, Qian Y, Hirose H, Yokoyama Y, Ikeshima R, Hiraki M, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Yamamoto H. A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells.

    MCT. 2018 May 17(5) 977-987.

  7. Harada M, Okuzaki D, Takeda J, Motoike Y, Koshikawa M, Watanabe E, Ozaki Y. Next Generation Sequencing Reveals Intra-Cardiac/Extra-Cardiac Circulating MicroRNA Transcriptomes in Atrial Fibrillation.

    CIRCULATION 2018 Nov 138.

  8. Osa, A.; Uenami, T.; Koyama, S.; Fujimoto, K.; Okuzaki, D.; Takimoto, T.; Hirata, H.; Yano, Y.; Yokota, S.; Kinehara, Y.; Naito, Y.; Otsuka, T.; Kanazu, M.; Kuroyama, M.; Hamaguchi, M.; Koba, T.; Futami, Y.; Ishijima, M.; Suga, Y.; Akazawa, Y.; Machiyama, H.; Iwahori, K.; Takamatsu, H.; Nagatomo, I.; Takeda, Y.; Kida, H.; Akbay, E. A.; Hammerman, P. S.; Wong, K.-K.; Dranoff, G.; Mori, M.; Kijima, T.; Kumanogoh, A. Clinical Implications of Monitoring Nivolumab Immunokinetics in Non-Small Cell Lung Cancer Patients.

    JCI Insight 2018, 3 (19).

  9. Matsuura, Y.; Kikuta, J.; Kishi, Y.; Hasegawa, T.; Okuzaki, D.; Hirano, T.; Minoshima, M.; Kikuchi, K.; Kumanogoh, A.; Ishii, M. In Vivo Visualisation of Different Modes of Action of Biological DMARDs Inhibiting Osteoclastic Bone Resorption.

    Ann Rheum Dis. 2018 Aug; 77 (8), 1219–1225.

  10. Kayama, H.; Kohyama, M.; Okuzaki, D.; Motooka, D.; Barman, S.; Okumura, R.; Muneta, M.; Hoshino, K.; Sasaki, I.; Ise, W.; Matsuno, H.; Nishimura, J.; Kurosaki, T.; Nakamura, S.; Arase, H.; Kaisho, T.; Takeda, K. Heme Ameliorates Dextran Sodium Sulfate-Induced Colitis through Providing Intestinal Macrophages with Noninflammatory Profiles.

    Proc Natl Acad Sci U.S.A. 2018 Aug 14; 115 (33), 8418–8423.

  11. Kang, S.; Nakanishi, Y.; Kioi, Y.; Okuzaki, D.; Kimura, T.; Takamatsu, H.; Koyama, S.; Nojima, S.; Nishide, M.; Hayama, Y.; Kinehara, Y.; Kato, Y.; Nakatani, T.; Shimogori, T.; Takagi, J.; Toyofuku, T.; Kumanogoh, A. Semaphorin 6D Reverse Signaling Controls Macrophage Lipid Metabolism and Anti-Inflammatory Polarization.

    Nat Immunol. 2018, 19 (6), 561–570.

  12. Doi, Y.; Yokota, T.; Satoh, Y.; Okuzaki, D.; Tokunaga, M.; Ishibashi, T.; Sudo, T.; Ueda, T.; Shingai, Y.; Ichii, M.; Tanimura, A.; Ezoe, S.; Shibayama, H.; Kohwi-Shigematsu, T.; Takeda, J.; Oritani, K.; Kanakura, Y. Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate.

    Cell Rep. 2018, 23 (11), 3223–3235.

  13. Inoue, A.; Mizushima, T.; Wu, X.; Okuzaki, D.; Kambara, N.; Ishikawa, S.; Wang, J.; Qian, Y.; Hirose, H.; Yokoyama, Y.; Ikeshima, R.; Hiraki, M.; Miyoshi, N.; Takahashi, H.; Haraguchi, N.; Hata, T.; Matsuda, C.; Doki, Y.; Mori, M.; Yamamoto, H. A MiR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-ΚB Signaling in KRAS-Mutant Colon Cancer Cells.

    Mol Cancer Ther. 2018 May; 17 (5), 977–987.

  14. Park, H.; Ohshima, K.; Nojima, S.; Tahara, S.; Kurashige, M.; Hori, Y.; Okuzaki, D.; Wada, N.; Ikeda, J.-I.; Morii, E. Adenylosuccinate Lyase Enhances Aggressiveness of Endometrial Cancer by Increasing Killer Cell Lectin-like Receptor C3 Expression by Fumarate.

    Lab Invest. 2018, 98 (4), 449–461.

  15. Yamanishi, K.; Mukai, K.; Hashimoto, T.; Ikubo, K.; Nakasho, K.; El-Darawish, Y.; Li, W.; Okuzaki, D.; Watanabe, Y.; Hayakawa, T.; Nojima, H.; Yamanishi, H.; Okamura, H.; Matsunaga, H. Physiological and Molecular Effects of Interleukin-18 Administration on the Mouse Kidney.

    J Transl Med. 2018 Mar 7; 16 (1), 51.

  16. Yabuta, N.; Ota, C.; Sasakura, T.; Naito, Y.; Okuzaki, D.; Fukushima, K.; Nojima, H. Late Cornified Envelope 1C (LCE1C), a Transcriptional Target of TAp63 Phosphorylated at T46/T281, Interacts with PRMT5.

    Sci Rep. 2018 Mar 20; 8 (1), 4892.

2017開く
  1. Ono, C.; Fukuhara, T.; Motooka, D.; Nakamura, S.; Okuzaki, D.; Yamamoto, S.; Tamura, T.; Mori, H.; Sato, A.; Uemura, K.; Fauzyah, Y.; Kurihara, T.; Suda, T.; Nishio, A.; Hmwe, S. S.; Okamoto, T.; Tatsumi, T.; Takehara, T.; Chayama, K.; Wakita, T.; Koike, K.; Matsuura, Y. Characterization of MiR-122-Independent Propagation of HCV.

    PLoS Pathog. 2017, 13 (5), e1006374.

  2. Okuzaki, D.; Ota, K.; Takatsuki, S.-I.; Akiyoshi, Y.; Naoi, K.; Yabuta, N.; Saji, T.; Nojima, H. FCN1 (M-Ficolin), Which Directly Associates with Immunoglobulin G1, Is a Molecular Target of Intravenous Immunoglobulin Therapy for Kawasaki Disease.

    Sci Rep 2017, 7 (1), 11334.

  3. Hosokawa, T.; Kimura, T.; Nada, S.; Okuno, T.; Ito, D.; Kang, S.; Nojima, S.; Yamashita, K.; Nakatani, T.; Hayama, Y.; Kato, Y.; Kinehara, Y.; Nishide, M.; Mikami, N.; Koyama, S.; Takamatsu, H.; Okuzaki, D.; Ohkura, N.; Sakaguchi, S.; Okada, M.; Kumanogoh, A. Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.

    J Immunol. 2017 Sep 15; 199 (6), 2008–2019.

  4. Okamoto T, Yamashita K, Suzuki K, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Daron M Stanley, Moriishi K, Matsuura Y. JMJD5 regulates HBV replication through interaction with HBx.

    ASM J 2017 Apr.

  5. Minamitani, T.; Ma, Y.; Zhou, H.; Kida, H.; Tsai, C.-Y.; Obana, M.; Okuzaki, D.; Fujio, Y.; Kumanogoh, A.; Zhao, B.; Kikutani, H.; Kieff, E.; Gewurz, B. E.; Yasui, T. Mouse Model of Epstein-Barr Virus LMP1- and LMP2A-Driven Germinal Center B-Cell Lymphoproliferative Disease.

    Proc Natl Acad. Sci. U.S.A. 2017, 114 (18), 4751–4756.

  6. Kitada, S.; Kayama, H.; Okuzaki, D.; Koga, R.; Kobayashi, M.; Arima, Y.; Kumanogoh, A.; Murakami, M.; Ikawa, M.; Takeda, K. BATF2 Inhibits Immunopathological Th17 Responses by Suppressing Il23a Expression during Trypanosoma Cruzi Infection.

    J. Exp. Med. 2017, 214 (5), 1313–1331.

  7. Ohshima, K.; Nojima, S.; Tahara, S.; Kurashige, M.; Hori, Y.; Hagiwara, K.; Okuzaki, D.; Oki, S.; Wada, N.; Ikeda, J.-I.; Kanai, Y.; Morii, E. Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer.

    Sci Rep 2017 Mar 30; 7, 45504.

  8. Fujimoto, K.; Kinoshita, M.; Tanaka, H.; Okuzaki, D.; Shimada, Y.; Kayama, H.; Okumura, R.; Furuta, Y.; Narazaki, M.; Tamura, A.; Hatakeyama, S.; Ikawa, M.; Tsuchiya, K.; Watanabe, M.; Kumanogoh, A.; Tsukita, S.; Takeda, K. Regulation of Intestinal Homeostasis by the Ulcerative Colitis-Associated Gene RNF186.

    Mucosal Immunol 2017, 10 (2), 446–459.

  9. Nishio, A.; Tatsumi, T.; Nawa, T.; Suda, T.; Yoshioka, T.; Onishi, Y.; Aono, S.; Shigekawa, M.; Hikita, H.; Sakamori, R.; Okuzaki, D.; Fukuhara, T.; Matsuura, Y.; Hiramatsu, N.; Takehara, T. CD14+ Monocyte-Derived Galectin-9 Induces Natural Killer Cell Cytotoxicity in Chronic Hepatitis C.

    Hepatology 2017, 65 (1), 18–31.

  10. Hagiyama, M.; Yabuta, N.; Okuzaki, D.; Inoue, T.; Takashima, Y.; Kimura, R.; Ri, A.; Ito, A. Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association with Cell Shape and Cytoskeletal Modifications.

    Front Physiol 2017, 8, 997.

  11. Okuzaki D, Ota K, Takatsuki SI, Akiyoshi Y, Naoi K, Yabuta N, Saji T, Nojima H. FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease.

    Sci Rep. 2017 Sep 12;7(1):11334. doi: 10.1038/s41598-017-11108-0.

  12. Kimura, T., Nada, S., Takegahara, N., Okuno, T., Nojima, S., Kang, S., Ito, D., Morimoto, K., Hosokawa, T., Hayama, Y., Mitsui, Y., Sakurai, N., Sarashina-Kida, H., Nishide, M., Maeda, Y., Takamatsu, H., Okuzaki, D., Yamada, M., Okada, M., Kumanogoh, A. Erratum: Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.

    Nature communications 2017 8 14711-14711.

2016開く
  1. Fujiwara, M.; Kubota, T.; Wang, W.; Ohata, Y.; Miura, K.; Kitaoka, T.; Okuzaki, D.; Namba, N.; Michigami, T.; Kitabatake, Y.; Ozono, K. Successful Induction of Sclerostin in Human-Derived Fibroblasts by 4 Transcription Factors and Its Regulation by Parathyroid Hormone, Hypoxia, and Prostaglandin E2. Bone 2016, 85, 91–98.
  2. Okuzaki, D.; Yoshizaki, K.; Tanaka, T.; Hirano, T.; Fukushima, K.; Washio, T.; Nojima, H. Microarray and Whole-Exome Sequencing Analysis of Familial Behçet’s Disease Patients.

    Sci Rep 2016, 6, 19456.

  3. Matsuyama, R.; Okuzaki, D.; Okada, M.; Oneyama, C. MicroRNA-27b Suppresses Tumor Progression by Regulating ARFGEF1 and Focal Adhesion Signaling.

    Cancer Sci. 2016, 107 (1), 28–35.

  4. Kouwaki, T.; Okamoto, T.; Ito, A.; Sugiyama, Y.; Yamashita, K.; Suzuki, T.; Kusakabe, S.; Hirano, J.; Fukuhara, T.; Yamashita, A.; Saito, K.; Okuzaki, D.; Watashi, K.; Sugiyama, M.; Yoshio, S.; Standley, D. M.; Kanto, T.; Mizokami, M.; Moriishi, K.; Matsuura, Y. Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx.

    J Virol. 2016, 90 (7), 3530–3542.

  5. Ohno, S.; Ikeda, J.-I.; Naito, Y.; Okuzaki, D.; Sasakura, T.; Fukushima, K.; Nishikawa, Y.; Ota, K.; Kato, Y.; Wang, M.; Torigata, K.; Kasama, T.; Uchihashi, T.; Miura, D.; Yabuta, N.; Morii, E.; Nojima, H. Comprehensive Phenotypic Analysis of Knockout Mice Deficient in Cyclin G1 and Cyclin G2.

    Sci Rep 2016, 6, 39091.

  6. Mokutani, Y.; Uemura, M.; Munakata, K.; Okuzaki, D.; Haraguchi, N.; Takahashi, H.; Nishimura, J.; Hata, T.; Murata, K.; Takemasa, I.; Mizushima, T.; Doki, Y.; Mori, M.; Yamamoto, H. Down-Regulation of MicroRNA-132 Is Associated with Poor Prognosis of Colorectal Cancer.

    Ann Surg Oncol. 2016, 23 (Suppl 5), 599–608.

  7. Barman, S.; Kayama, H.; Okuzaki, D.; Ogino, T.; Osawa, H.; Matsuno, H.; Mizushima, T.; Mori, M.; Nishimura, J.; Takeda, K. Identification of a Human Intestinal Myeloid Cell Subset That Regulates Gut Homeostasis.

    Int Immunol. 2016, 28 (11), 533–545.

  8. 太田知絵, 篠倉悠久, 奥崎大介, 福島孝士朗, 向井智美, 藪田紀一, 野島博. GAKがリン酸化したTAp63はLCE1C遺伝子を特異的に転写誘導する.

    日本分子生物学会年会プログラム・要旨集(Web) 39th 2016年

  9. Kimura, T.; Nada, S.; Takegahara, N.; Okuno, T.; Nojima, S.; Kang, S.; Ito, D.; Morimoto, K.; Hosokawa, T.; Hayama, Y.; Mitsui, Y.; Sakurai, N.; Sarashina-Kida, H.; Nishide, M.; Maeda, Y.; Takamatsu, H.; Okuzaki, D.; Yamada, M.; Okada, M.; Kumanogoh, A. Polarization of M2 Macrophages Requires Lamtor1 That Integrates Cytokine and Amino-Acid Signals.

    Nat Commun 2016, 7, 13130.

  10. Yamanishi, K.; Maeda, S.; Kuwahara-Otani, S.; Watanabe, Y.; Yoshida, M.; Ikubo, K.; Okuzaki, D.; El-Darawish, Y.; Li, W.; Nakasho, K.; Nojima, H.; Yamanishi, H.; Hayakawa, T.; Okamura, H.; Matsunaga, H. Interleukin-18-Deficient Mice Develop Dyslipidemia Resulting in Nonalcoholic Fatty Liver Disease and Steatohepatitis.

    Transl Res 2016, 173, 101-114.e7.

  11. Yasugi, M.; Okuzaki, D.; Kuwana, R.; Takamatsu, H.; Fujita, M.; Sarker, M. R.; Miyake, M. Transcriptional Profile during Deoxycholate-Induced Sporulation in a Clostridium Perfringens Isolate Causing Foodborne Illness.

    Appl Environ Microbiol. 2016, 82 (10), 2929–2942.

  12. Wada, N.; Ikeda, J.-I.; Nojima, S.; Tahara, S.-I.; Ohshima, K.; Okuzaki, D.; Morii, E. Requirement of CXCL12-CXCR7 Signaling for CD20(-) CD138(-) Double-Negative Population in Lymphoplasmacytic Lymphoma.

    Lab Invest. 2016, 96 (5), 517–525.

  13. Nakamura, S.; Horie, M.; Daidoji, T.; Honda, T.; Yasugi, M.; Kuno, A.; Komori, T.; Okuzaki, D.; Narimatsu, H.; Nakaya, T.; Tomonaga, K. Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.

    J Virol. 2016, 90 (4), 1788–1801.

  14. Torigata, K.; Okuzaki, D.; Mukai, S.; Hatanaka, A.; Ohka, F.; Motooka, D.; Nakamura, S.; Ohkawa, Y.; Yabuta, N.; Kondo, Y.; Nojima, H. LATS2 Positively Regulates Polycomb Repressive Complex 2.

    PLoS ONE 2016, 11 (7), e0158562.

  15. Sudo, T.; Yokota, T.; Okuzaki, D.; Ueda, T.; Ichii, M.; Ishibashi, T.; Isono, T.; Habuchi, Y.; Oritani, K.; Kanakura, Y. Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.

    PLoS ONE 2016, 11 (4), e0154189.

  16. Nagasawa, Y.; Okuzaki, D.; Muso, E.; Yamamoto, R.; Shinzawa, M.; Iwasaki, Y.; Iwatani, H.; Nakanishi, T.; Isaka, Y.; Nojima, H. IFI27 Is a Useful Genetic Marker for Diagnosis of Immunoglobulin A Nephropathy and Membranous Nephropathy Using Peripheral Blood.

    PLoS ONE 2016, 11 (4), e0153252.

  17. Wada, N., Ikeda, J.-I., Nojima, S., Tahara, S.-I., Ohshima, K., Okuzaki, D., Morii, E. Requirement of CXCL12-CXCR7 signaling for CD20 - CD138 - double-negative population in lymphoplasmacytic lymphoma.

    Laboratory Investigation 2016 96(5) 517-525

2015開く
  1. Nishikawa Y, Okuzaki D, Fukushima K, Mukai S, Ohno S, Ozaki Y, Yabuta N, Nojima H. Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells.

    PLoS One. 2015 Jul 31;10(7):e0134137. doi: 10.1371/journal.pone.0134137. eCollection 2015.

  2. Watanabe, Y.; Yoshida, M.; Yamanishi, K.; Yamamoto, H.; Okuzaki, D.; Nojima, H.; Yasunaga, T.; Okamura, H.; Matsunaga, H.; Yamanishi, H. Genetic Analysis of Genes Causing Hypertension and Stroke in Spontaneously Hypertensive Rats: Gene Expression Profiles in the Kidneys.

    Int J Mol Med. 2015 Sep; 36 (3), 712–724.

  3. Nonaka, R.; Miyake, Y.; Hata, T.; Kagawa, Y.; Kato, T.; Osawa, H.; Nishimura, J.; Ikenaga, M.; Murata, K.; Uemura, M.; Okuzaki, D.; Takemasa, I.; Mizushima, T.; Yamamoto, H.; Doki, Y.; Mori, M. Circulating MiR-103 and MiR-720 as Novel Serum Biomarkers for Patients with Colorectal Cancer.

    Int J Oncol. 2015, 47 (3), 1097–1102.

  4. Minamitani, T.; Yasui, T.; Ma, Y.; Zhou, H.; Okuzaki, D.; Tsai, C.-Y.; Sakakibara, S.; Gewurz, B. E.; Kieff, E.; Kikutani, H. Evasion of Affinity-Based Selection in Germinal Centers by Epstein-Barr Virus LMP2A.

    Proc Natl Acad Sci U.S.A. 2015, 112 (37), 11612–11617.

  5. Inoue, H.; Matsuzaki, Y.; Tanaka, A.; Hosoi, K.; Ichimura, K.; Arasaki, K.; Wakana, Y.; Asano, K.; Tanaka, M.; Okuzaki, D.; Yamamoto, A.; Tani, K.; Tagaya, M. γ-SNAP Stimulates Disassembly of Endosomal SNARE Complexes and Regulates Endocytic Trafficking Pathways.

    J Cell Sci. 2015, 128 (15), 2781–2794.

  6. Ouji, Y.; Ishizaka, S.; Nakamura-Uchiyama, F.; Okuzaki, D.; Yoshikawa, M. Partial Maintenance and Long-Term Expansion of Murine Skin Epithelial Stem Cells by Wnt-3a in Vitro. J.

    Invest Dermatol. 2015, 135 (6), 1598–1608.

  7. Yokota, T.; Oritani, K.; Sudo, T.; Ishibashi, T.; Doi, Y.; Habuchi, Y.; Ichii, M.; Fukushima, K.; Okuzaki, D.; Tomizuka, K.; Yamawaki, K.; Kakitani, M.; Shimono, A.; Morii, E.; Kincade, P. W.; Kanakura, Y. Estrogen-Inducible SFRP5 Inhibits Early B-Lymphopoiesis in Vivo, but Not during Pregnancy.

    Eur J Immunol. 2015, 45 (5), 1390–1401.

  8. Naito, A.; Yamamoto, H.; Kagawa, Y.; Naito, Y.; Okuzaki, D.; Otani, K.; Iwamoto, Y.; Maeda, S.; Kikuta, J.; Nishikawa, K.; Uemura, M.; Nishimura, J.; Hata, T.; Takemasa, I.; Mizushima, T.; Ishii, H.; Doki, Y.; Mori, M.; Ishii, M. RFPL4A Increases the G1 Population and Decreases Sensitivity to Chemotherapy in Human Colorectal Cancer Cells.

    J Biol Chem. 2015, 290 (10), 6326–6337.

  9. Fujita, T.; Yuno, M.; Okuzaki, D.; Ohki, R.; Fujii, H. Identification of Non-Coding RNAs Associated with Telomeres Using a Combination of EnChIP and RNA Sequencing.

    PLoS ONE 2015, 10 (4), e0123387.

2014開く
  1. Nonaka, R.; Nishimura, J.; Kagawa, Y.; Osawa, H.; Hasegawa, J.; Murata, K.; Okamura, S.; Ota, H.; Uemura, M.; Hata, T.; Takemasa, I.; Mizushima, T.; Okuzaki, D.; Yamamoto, H.; Doki, Y.; Mori, M. Circulating MiR-199a-3p as a Novel Serum Biomarker for Colorectal Cancer.

    Oncol Rep. 2014, 32 (6), 2354–2358.

  2. 福島 孝士朗, 奥崎 大介, 大野 将一, 野崎 正美, 藪田 紀一, 野島 博. ウィザフェリンAはc-Fos誘導を介してスフェロイド形成能を持つ前立腺がん細胞の選択的な細胞死を引き起こす(Withaferin A selectively causes cell death in spheroid forming prostate cancer cells through induction of c-Fos). 日本癌学会総会記事 73回 P-2405 2014年9月
  3. 篠倉 悠久, 奥崎 大介, 内藤 陽子, 藪田 紀一, 野島 博. ゲフィチニブとルテオリンの同時投与はヒト前立腺がん細胞株PC-3細胞の効果的な細胞死を誘導する(Co-administration of gefitinib and luteolin induced efficient cell death of human prostate cancer PC-3 cells). 日本癌学会総会記事 73回 P-1388 2014年9月
  4. Ono C, Fukuhara T, Yamamoto S, Wada M, Okamoto T, Okuzaki, D, Matsuura Y. Characterization of HCV propagation in miR-122 knockout cells.

    Journals Plos Org 2014 Sep.

  5. Chikako Ono C, Fukuhara T, Shiokawa M, Yamamoto S, Wada M, Okamoto T, Okuzaki D, Matsuura Y. Characterization of HCV Propagation in miR-122 Knockout Cells.

    Journals Plos Org 2014 Jun.

  6. 鳥形 康輔, 奥崎 大介, 畑中 彬良, 大岡 史治, 大川 恭行, 小根山 千歳, 近藤 豊, 藪田 紀一, 野島 博.

    エピゲノムの多様性・特異性を生み出す新規上流シグナルの探索. 2014年5月

  7. Fukuhara, T.; Wada, M.; Nakamura, S.; Ono, C.; Shiokawa, M.; Yamamoto, S.; Motomura, T.; Okamoto, T.; Okuzaki, D.; Yamamoto, M.; Saito, I.; Wakita, T.; Koike, K.; Matsuura, Y. Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles.

    PLoS Pathog. 2014, 10 (12), e1004534.

  8. 155. 前田裕輔, 木下タロウ, 奥崎大介.

    ゴルジ装置の酸性環境と膜接触場を介した細胞内コレステロールの生合成・輸送の調節, 日本生化学会大会(Web) 87th [1S04-5] 2014年

  9. Fujita, N.; Oritani, K.; Ichii, M.; Yokota, T.; Saitoh, N.; Okuzaki, D.; Sekine, Y.; Kon, S.; Muromoto, R.; Saitoh, K.; Yoshimura, A.; Matsuda, T.; Kanakura, Y. Signal-Transducing Adaptor Protein-2 Regulates Macrophage Migration into Inflammatory Sites during Dextran Sodium Sulfate Induced Colitis. Eur.

    J Immunol. 2014, 44 (6), 1791–1801.

  10. Yoshida, M.; Watanabe, Y.; Yamanishi, K.; Yamashita, A.; Yamamoto, H.; Okuzaki, D.; Shimada, K.; Nojima, H.; Yasunaga, T.; Okamura, H.; Matsunaga, H.; Yamanishi, H. Analysis of Genes Causing Hypertension and Stroke in Spontaneously Hypertensive Rats: Gene Expression Profiles in the Brain.

    Int J Mol Med. 2014, 33 (4), 887–896.

  11. Sakurai, M. A.; Ozaki, Y.; Okuzaki, D.; Naito, Y.; Sasakura, T.; Okamoto, A.; Tabara, H.; Inoue, T.; Hagiyama, M.; Ito, A.; Yabuta, N.; Nojima, H. Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of MiR-630.

    PLoS ONE 2014, 9 (6), e100124.

2013開く
  1. Ogino, T.; Nishimura, J.; Barman, S.; Kayama, H.; Uematsu, S.; Okuzaki, D.; Osawa, H.; Haraguchi, N.; Uemura, M.; Hata, T.; Takemasa, I.; Mizushima, T.; Yamamoto, H.; Takeda, K.; Doki, Y.; Mori, M. Increased Th17-Inducing Activity of CD14+ CD163 Low Myeloid Cells in Intestinal Lamina Propria of Patients with Crohn’s Disease.

    Gastroenterology 2013, 145 (6), 1380-1391.e1.

  2. Muso, E.; Okuzaki, D.; Kobayashi, S.; Iwasaki, Y.; Sakurai, M. A.; Ito, A.; Nojima, H. Ficolin-1 Is up-Regulated in Leukocytes and Glomeruli from Microscopic Polyangiitis Patients.

    Autoimmunity 2013, 46 (8), 513–524.

  3. Nagi-Miura, N.; Okuzaki, D.; Torigata, K.; Sakurai, M. A.; Ito, A.; Ohno, N.; Nojima, H. CAWS Administration Increases the Expression of Interferon γ and Complement Factors That Lead to Severe Vasculitis in DBA/2 Mice.

    BMC Immunol. 2013, 14, 44.

  4. Katahira, J.; Okuzaki, D.; Inoue, H.; Yoneda, Y.; Maehara, K.; Ohkawa, Y. Human TREX Component Thoc5 Affects Alternative Polyadenylation Site Choice by Recruiting Mammalian Cleavage Factor I.

    Nucleic Acids Res. 2013, 41 (14), 7060–7072.

  5. 小野慎子, 福原崇介, 塩川舞, 山本聡美, 和田真実, 岡本徹, 奥崎大介, 松浦善治.

    miR-122遺伝子欠損Huh7細胞株におけるC型肝炎ウイルスの増殖, 日本ウイルス学会学術集会プログラム・抄録集 61st 2013年

  6. Yamamoto, H.; Okuzaki, D.; Yamanishi, K.; Xu, Y.; Watanabe, Y.; Yoshida, M.; Yamashita, A.; Goto, N.; Nishiguchi, S.; Shimada, K.; Nojima, H.; Yasunaga, T.; Okamura, H.; Matsunaga, H.; Yamanishi, H. Genetic Analysis of Genes Causing Hypertension and Stroke in Spontaneously Hypertensive Rats.

    Int J Mol Med. 2013, 31 (5), 1057–1065.

  7. Yabuta, N.; Mukai, S.; Okamoto, A.; Okuzaki, D.; Suzuki, H.; Torigata, K.; Yoshida, K.; Okada, N.; Miura, D.; Ito, A.; Ikawa, M.; Okabe, M.; Nojima, H. N-Terminal Truncation of Lats1 Causes Abnormal Cell Growth Control and Chromosomal Instability.

    J Cell Sci. 2013, 126 (Pt 2), 508–520.

  8. Oneyama, C.; Kito, Y.; Asai, R.; Ikeda, J.; Yoshida, T.; Okuzaki, D.; Kokuda, R.; Kakumoto, K.; Takayama, K.; Inoue, S.; Morii, E.; Okada, M. MiR-424/503-Mediated Rictor Upregulation Promotes Tumor Progression.

    PLoS ONE 2013, 8 (11), e80300.

  9. Kagawa, Y.; Matsumoto, S.; Kamioka, Y.; Mimori, K.; Naito, Y.; Ishii, T.; Okuzaki, D.; Nishida, N.; Maeda, S.; Naito, A.; Kikuta, J.; Nishikawa, K.; Nishimura, J.; Haraguchi, N.; Takemasa, I.; Mizushima, T.; Ikeda, M.; Yamamoto, H.; Sekimoto, M.; Ishii, H.; Doki, Y.; Matsuda, M.; Kikuchi, A.; Mori, M.; Ishii, M. Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion in Vivo.

    PLoS ONE. 2013, 8 (12), e83629.

2012開く
  1. Fukuhara, T.; Kambara, H.; Shiokawa, M.; Ono, C.; Katoh, H.; Morita, E.; Okuzaki, D.; Maehara, Y.; Koike, K.; Matsuura, Y. Expression of MicroRNA MiR-122 Facilitates an Efficient Replication in Nonhepatic Cells upon Infection with Hepatitis C Virus.

    J Virol. 2012, 86 (15), 7918–7933.

  2. Oneyama, C.; Morii, E.; Okuzaki, D.; Takahashi, Y.; Ikeda, J.; Wakabayashi, N.; Akamatsu, H.; Tsujimoto, M.; Nishida, T.; Aozasa, K.; Okada, M. MicroRNA-Mediated Upregulation of Integrin-Linked Kinase Promotes Src-Induced Tumor Progression.

    Oncogene 2012, 31 (13), 1623–1635.

2011開く
  1. Oneyama, C.; Ikeda, J.; Okuzaki, D.; Suzuki, K.; Kanou, T.; Shintani, Y.; Morii, E.; Okumura, M.; Aozasa, K.; Okada, M. MicroRNA-Mediated Downregulation of MTOR/FGFR3 Controls Tumor Growth Induced by Src-Related Oncogenic Pathways.

    Oncogene 2011, 30 (32), 3489–3501.

  2. Okuzaki, D.; Kimura, S.; Yabuta, N.; Ohmine, T.; Nojima, H. LeukoCatch, a Quick and Efficient Tool for the Preparation of Leukocyte Extracts from Blood.

    BMC Clin Pathol 2011, 11, 9.

  3. Honda, T.; Fujino, K.; Okuzaki, D.; Ohtaki, N.; Matsumoto, Y.; Horie, M.; Daito, T.; Itoh, M.; Tomonaga, K. Upregulation of Insulin-like Growth Factor Binding Protein 3 in Astrocytes of Transgenic Mice That Express Borna Disease Virus Phosphoprotein.

    J Virol. 2011, 85 (9), 4567–4571.

  4. Iwatani, H.; Iio, K.; Nagasawa, Y.; Yamamoto, R.; Horii, A.; Okuzaki, D.; Inohara, H.; Nojima, H.; Imai, E.; Rakugi, H.; Isaka, Y. Microarray Analysis of Tonsils of IgA Nephropathy Patients. Adv.

    Otorhinolaryngol. 2011, 72, 75–78.

2010開く
  1. Tougan, T.; Kasama, T.; Ohtaka, A.; Okuzaki, D.; Saito, T. T.; Russell, P.; Nojima, H. The Mek1 Phosphorylation Cascade Plays a Role in Meiotic Recombination of Schizosaccharomyces Pombe.

    Cell Cycle 2010, 9 (23), 4688–4702.

  2. Okuzaki, D.; Fukushima, T.; Tougan, T.; Ishii, T.; Kobayashi, S.; Yoshizaki, K.; Akita, T.; Nojima, H. GenopalTM: A Novel Hollow Fibre Array for Focused Microarray Analysis.

    DNA Res. 2010, 17 (6), 369–379.

  3. Funato, Y.; Terabayashi, T.; Sakamoto, R.; Okuzaki, D.; Ichise, H.; Nojima, H.; Yoshida, N.; Miki, H. Nucleoredoxin Sustains Wnt/β-Catenin Signaling by Retaining a Pool of Inactive Dishevelled Protein.

    Curr Biol. 2010, 20 (21), 1945–1952.

  4. Okuzaki, D., Fukushima, T., Tougan, T., Ishii, T., Kobayashi, S., Yoshizaki, K., Akita, T., Nojima, H. Genopal™: A novel hollow fibre array for focused microarray analysis.

    DNA Research. 2010 17(6) 369-379.

  5. Okuzaki, D.; Kasama, T.; Hirata, A.; Ohtaka, A.; Kakegawa, R.; Nojima, H. Spo5 Phosphorylation Is Essential for Its Own Timely Degradation and for Successful Meiosis in Schizosaccharomyces Pombe.

    Cell Cycle. 2010, 9 (18), 3751–3760.

  6. Shigehisa, A.; Okuzaki, D.; Kasama, T.; Tohda, H.; Hirata, A.; Nojima, H. Mug28, a Meiosis-Specific Protein of Schizosaccharomyces Pombe, Regulates Spore Wall Formation.

    Mol Biol Cell 2010, 21 (12), 1955–1967.

  7. Iio, K.; Nagasawa, Y.; Iwatani, H.; Yamamoto, R.; Horii, A.; Okuzaki, D.; Furumatsu, Y.; Inohara, H.; Nojima, H.; Imai, E.; Isaka, Y.; Rakugi, H. Microarray Analysis of Tonsils in Immunoglobulin A Nephropathy Patients. Biochem. Biophys.

    Res Commun. 2010, 393 (4), 565–570.

2008開く
  1. Kobayashi, S.; Ito, A.; Okuzaki, D.; Onda, H.; Yabuta, N.; Nagamori, I.; Suzuki, K.; Hashimoto, H.; Nojima, H. Expression Profiling of PBMC-Based Diagnostic Gene Markers Isolated from Vasculitis Patients.

    DNA Res. 2008, 15 (4), 253–265.

  2. Tougan T, Okuzaki D, Nojima H. Chum-RNA allows preparation of a high-quality cDNA library from a single-cell quantity of mRNA without PCR amplification.

    Nucleic Acids Research 2008 Sep 36(15) e92.

  3. Ohtaka, A.; Okuzaki, D.; Nojima, H. Mug27 Is a Meiosis-Specific Protein Kinase That Functions in Fission Yeast Meiosis II and Sporulation.

    J Cell Sci. 2008, 121 (Pt 9), 1547–1558.

  4. Tougan, T.; Onda, H.; Okuzaki, D.; Kobayashi, S.; Hashimoto, H.; Nojima, H. Focused Microarray Analysis of Peripheral Mononuclear Blood Cells from Churg-Strauss Syndrome Patients.

    DNA Res. 2008, 15 (2), 103–114.

2007開く
  1. Ohtaka A, Saito TT, Okuzaki D, Nojima H. Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe.

    Cell Div. 2007 May 18;2:14. doi: 10.1186/1747-1028-2-14.

  2. Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fujimori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Nojima H. Lats2 is an essential mitotic regulator required for the coordination of cell division.

    J Biol Chem. 2007 Jun 29;282(26):19259-71. doi: 10.1074/jbc.M608562200. Epub 2007 May 3.

  3. Ohtaka A, Okuzaki D, Saito TT, Nojima H. Mcp4, a meiotic coiled-coil protein, plays a role in F-actin positioning during Schizosaccharomyces pombe meiosis. Eukaryot Cell. 2007 Jun;6(6):971-83. doi: 10.1128/EC.00016-07.

    Epub 2007 Apr 13.

2006開く
  1. Nakamura N, Shimaoka Y, Tougan T, Onda H, Okuzaki D, Zhao H, Fujimori A, Yabuta N, Nagamori I, Tanigawa A, Sato J, Oda T, Hayashida K, Suzuki R, Yukioka M, Nojima H, Ochi T. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.

    DNA Res. 2006 Aug 31;13(4):169-83. doi: 10.1093/dnares/dsl006.

  2. Kasama T, Shigehisa A, Hirata A, Saito TT, Tougan T, Okuzaki D, Nojima H. Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci.

    Eukaryot Cell. 2006 Aug;5(8):1301-13. doi: 10.1128/EC.00099-06.

  3. Saito TT, Okuzaki D, Nojima H. Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast.

    J Cell Biol. 2006 Apr 10;173(1):27-33. doi: 10.1083/jcb.200512129. Epub 2006 Apr 3.

2005開く
  1. Saito TT, Tougan T, Okuzaki D, Kasama T, Nojima H. Mcp6, a meiosis-specific coiled-coil protein of Schizosaccharomyces pombe, localizes to the spindle pole body and is required for horsetail movement and recombination.

    J Cell Sci. 2005 Jan 15;118(Pt 2):447-59. doi: 10.1242/jcs.01629.

2004開く
  1. Saito TT, Tougan T, Kasama T, Okuzaki D, Nojima H. Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination.

    Nucleic Acids Research. 2004 32(11) 3325-3339.

2003開く
  1. Okuzakil, D., Watanabe, T., Tanaka, S., Nojima, H. The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions.

    Genes and Genetic Systems. 2003 78(2) 113-26.

  2. Okuzaki, D., Satake, W., Hirata, A., Nojima, H. Fission yeast meu14+ is required for proper nuclear division and accurate forespore membrane formation during meiosis II.

    Journal of Cell Science. 2003 116(13) 2721-2735

2001開く
  1. Okuzaki, D., Nojima, H., Kcc4 associates with septin proteins of Saccharomyces cerevisiae.

    FEBS Letters. 2001 Feb 489(2-3) 197-201.

2000開く
  1. Tanaka Y, Okuzaki D, Yabuta N, Yoneki T, Nojima H. Rad24 is essential for proliferation of diploid cells in fission yeast.

    FEBS Letters. 2000 Feb 472(2-3) 254-258.

1999開く
  1. Shimada M, Okuzaki D, Tanaka S, Tougan T, Katsuyuki K. Tamai, Shimoda C, Nojima H,. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. Molecular

    Biology of the Cell. 1999 Dec 10(12) 3991-4003.

1997開く
  1. Okuzaki D, Tanaka S, Kanazawa H, Nojima H,. Gin4 of 5. cerevisiae is a bud neck protein that interacts with the Cdc28 complex.

    Genes to Cells . 1997 2(12) 753-770.

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